北京语言大学语言康复学院,北京,100083
纸质出版:2021
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谢点, 孔令志. 基于脑磁图的自闭症谱系障碍早期筛查和诊断指标[J]. 中国听力语言康复科学杂志, 2021,19(3):232-237.
谢点, 孔令志. Early Screening and Diagnostic Biomarkers of Autism Spectrum Disorders Based on Magnetoencephalography[J]. 2021, 19(3): 232-237.
自闭症谱系障碍(autism spectrum disorder
ASD)是以社交障碍、重复刻板行为和狭隘的兴趣为主要特征的神经发育障碍性疾病
其患病率呈逐年上升趋势。大量关于ASD的研究仅凭行为特征进行诊断
而ASD的病因、临床症状及并发症等都具有高度异质性
使得无法对ASD儿童进行早期的筛查和诊断
从而错过最佳治疗时机。基于生物学的标志物可以提供一种客观、容易量化的方式
不仅能够用于早期筛查诊断及预后
而且还可以用于药物开发和治疗疗效的反应指标。鉴于脑磁图(magnetoencephalography
MEG)相较于其他脑成像方法在ASD中的适用性及其优点
本文对ASD中MEG相关生物标志物的研究进行了综述
主要包括听觉诱发电位M50/M100、听觉失匹配磁场(magneticmis matchfiels
MMF)以及听觉gamma频段反应。
Autism Spectrum Disorder(ASD) is a neurodevelopmental disorder characterized by social impairments
repetitive stereotyped behaviors and narrow interests. Its prevalence is increasing year by year. Although there are a large number of studies on ASD
it is still diagnosed based on behavioral characteristics. The etiology
clinical symptoms and complications of ASD are highly heterogeneous
making it impossible to carry out early screening and diagnosis of ASD children
thereby missing the best time for treatment. Biologically based markers can provide an objective and a quantifiable method
not only for early screening diagnosis and prognosis
but also for drug development and therapeutic response indicators. In view of the advantages and applicability of magnetoencephalography(MEG) compared with other brain imaging methods in ASD
this article reviews the research of MEG-related biomarkers in ASD
mainly including auditory evoked potentials M50/M100
magnetic mismatch field(MMF) and auditory gamma band response.
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