Hearing loss is one of the common factors affecting normal interpersonal communication. In recent years

due to the improvement of the environment and the control of infection

genetic factors account for a relatively high proportion in the causes of hearing loss

of which 70% are nonsyndromic hearing loss. At present

124 causative genes associated with nonsyndromic hearing loss have been identified

including the alpha-tectorin（TECTA） gene. The gene is one of the major causative genes for autosomal dominant sensorineural hearing loss and mutations in the gene are responsible for DFNA8/12

DFNB21

and hearing loss in Jacobsen syndrome. To date

more than 80 TECTA gene mutations that may cause diseases have been reported in the literature

and the mutation sites were found to be closely related to the hearing loss phenotype. In view of the important role of the research on the structure

function and pathogenesis of TECTA gene in the diagnosis and prevention of diseases related to hearing loss

this paper reviews the research status of TECTA gene structure

known mutations and related diseases

aiming to make a systematic analysis of the correlation between the mutation of TECTA gene on the basis of understanding the structure and function of TECTA gene and its protein and hearing loss and provide scientific guidance for genetic screening

accurate diagnosis of diseases and future gene therapy.