爆震性耳聋临床表型及治疗效果与外周炎症细胞相关性分析

石敏; 朱玉莹; 吕萍; 李新建; 黄邦清; 彭新; 李北成; 杨颖; 刘明波; 朱玉华

您当前的位置：

首页 >

文章列表页 >

爆震性耳聋临床表型及治疗效果与外周炎症细胞相关性分析

临床研究 | 更新时间：2026-10-28

- 爆震性耳聋临床表型及治疗效果与外周炎症细胞相关性分析
- Correlation Analysis of Peripheral Inflammatory Cells and Clinical Phenotype and Treatment Effect of Explosive Deafness
- 中国听力语言康复科学杂志 2021年19卷第2期页码：83-87
- 作者机构：
  
  1. 解放军总医院海南医院耳鼻咽喉头颈外科
  2. 解放军总医院耳鼻咽喉头颈外科/国家耳鼻咽喉疾病临床医学研究中心/聋病教育部重点实验室/聋病防治北京市重点实验室
  3. 川北医学院附属医院耳鼻咽喉科
  4. 潍坊医学院耳鼻咽喉科教研室
- 作者简介：
- 基金信息：
  
  解放军总医院军事医学青年专项课题（QNC19051）
- DOI：
  中图分类号： R764.43
- 纸质出版：2021
- 稿件说明：
移动端阅览
[1]石敏,朱玉莹,吕萍,李新建,黄邦清,彭新,李北成,杨颖,刘明波,朱玉华.爆震性耳聋临床表型及治疗效果与外周炎症细胞相关性分析[J].中国听力语言康复科学杂志,2021,19(02):83-87.

石敏, 朱玉莹, 吕萍, et al. Correlation Analysis of Peripheral Inflammatory Cells and Clinical Phenotype and Treatment Effect of Explosive Deafness[J]. 2021, 19(2): 83-87.
[1]石敏,朱玉莹,吕萍,李新建,黄邦清,彭新,李北成,杨颖,刘明波,朱玉华.爆震性耳聋临床表型及治疗效果与外周炎症细胞相关性分析[J].中国听力语言康复科学杂志,2021,19(02):83-87. DOI：

石敏, 朱玉莹, 吕萍, et al. Correlation Analysis of Peripheral Inflammatory Cells and Clinical Phenotype and Treatment Effect of Explosive Deafness[J]. 2021, 19(2): 83-87. DOI：

摘要

目的通过分析爆震性耳聋发生后外周血炎症细胞指标变化

研究外周炎症细胞与爆震性耳聋临床表型及治疗效果相关性。方法对14例（16耳）爆震性耳聋发生后外周血炎症细胞指标变化进行分析

比较不同疗效的爆震性耳聋患者间外周血炎症细胞指标的分布特征。结果所有患者听力损失程度为轻度68.8%、中度25.0%、重度6.3%;其听力图类型主要为陡降型56.25%、平坦型31.25%、钟型6.25%;治疗前后比较其听觉阈值结果

250、1000、2000、4000Hz差异有统计学意义（P<0.05）;62.50%的患者中性粒细胞升高

50.00%的患者淋巴细胞降低

单核细胞值正常与降低患者分别各占37.50%

嗜酸性粒细胞降低的患者超过62.50%;经治疗

9耳有效

7耳无效

不同疗效患者间外周血炎症指标间差异没有统计学意义（P>0.05）。结论本研究尚未发现外周炎症细胞变化与噪声性耳聋临床表型及治疗预后直接相关

仍需未来加大样本量进一步研究。

Abstract

Objective To study the correlation between peripheral inflammatory cells and the clinical phenotype and treatment effect of explosive deafness by analyzing the changes of peripheral blood inflammatory cells after the occurrence of knock deafness. Methods The changes in peripheral blood inflammatory cell indexes of 14 patients（16 ears） with explosive deafness were analyzed

and the distribution characteristics of peripheral blood inflammatory cell indexes among patients with explosive deafness with different curative effects were compared. Results The hearing loss of all patients includes mild

moderate

and severe

accounting for 68.75%

25.00%

and 6.25% respectively; Their audiogram types are mainly steep drop

flat

and bell

accounting for 56.25%

31.25%

and 6.25% respectively; The audiology examination was completed before and after treatment

and the results of hearing threshold were compared before and after treatment. There were statistical differences between 250 Hz

1000 Hz

2000 Hz

and 4000 Hz（P<0.05）; 62.50% of patients had elevated neutrophils

50.00% of patients had decreased lymphocytes

37.50% of patients with normal and decreased monocyte values

and more than 62.50% of patients with decreased eosinophils; After treatment

9 ears were effective

7 ears were ineffective

and no statistical significance difference was found in the inflammation indexes of peripheral blood between patients with different curative effects（P>0.05）. Conclusion This study has not found that the changes of peripheral inflammatory cells are directly related to the clinical phenotype and treatment prognosis of noise-induced deafness

and further research is needed to increase the sample size in future studies.

关键词

Keywords

references

对Hensen细胞在耳蜗K + 循环中角色的新认识 [J]. 石敏,于宁,丁大雄,文艺,杨风波,胡一勇,李兴启,吕萍. 中华耳科学杂志 . 2020(03)

中性粒细胞淋巴细胞比值和血小板淋巴细胞比值与突发性聋相关性的研究 [J]. 宋少鹏,李进兴,李文文,马秀岚. 临床耳鼻咽喉头颈外科杂志 . 2018(19)

噪声引起小型猪耳蜗炎症复合体的激活及蛋白质组学研究 [J]. 塞娜,袁硕龙,郭维维,唐朝颖,张桐,赵伟豪,陈林军,徐良慰,时晰,张悦,邱仕伟,杨仕明,韩维举. 中华耳科学杂志 . 2018(04)

血常规相关指标对突聋患者预后的预测作用 [J]. 张思林,周文胜,胡仿玲,梁红星,江红群,余杰情. 听力学及言语疾病杂志 . 2018(01)

染料木素对噪声性聋的保护作用 [J]. 肖冰,姜明春,康颂建,孙宪昌. 中国眼耳鼻喉科杂志 . 2016(02)

突发性耳聋患者外周血白细胞计数及分属与初发听力损失和预后的相关性 [J]. 李璠,李峰,鲁建光. 哈尔滨医科大学学报 . 2015(04)

神经生长因子治疗爆震性耳聋的临床观察 [J]. 翟所强,于宁,朱玉华,秦贺. 中国医药导报 . 2010(04)

耳蜗病理生理学[M]. 人民军医出版社 , 李兴启, 2011

耳科学[M]. 上海科学技术出版社 , 姜泗长等主编, 2002

Investigation of the prognostic role of neutrophil-to-lymphocyte ratio in Idiopathic Sudden Sensorineural Hearing Loss based on propensity score matching: a retrospective observational study. [J] . Wu Shiyuan,Cao Zaizai,Shi Fangling,Chen Bobei. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies （EUFOS） : affiliated with the German Society for Oto-Rhino-Laryngology - . 2020 (7)

Macrophages in Noise-Exposed Cochlea: Changes, Regulation and the Potential Role. [J] . He Weiwei,Yu Jintao,Sun Yu,Kong Weijia. Aging and disease . 2020 (1)

Targeting Inflammatory Processes Mediated by TRPVI and TNF-α for Treating Noise-Induced Hearing Loss. [J] . Dhukhwa Asmita,Bhatta Puspanjali,Sheth Sandeep,Korrapati Krishi,Tieu Coral,Mamillapalli Chaitanya,Ramkumar Vickram,Mukherjea Debashree. Frontiers in cellular neuroscience . 2019

Noise-induced trauma produces a temporal pattern of change in blood levels of the outer hair cell biomarker prestin [J] . Kourosh Parham,Maheep Sohal,Mathieu Petremann,Charlotte Romanet,Audrey Broussy,Christophe Tran Van Ba,Jonas Dyhrfjeld-Johnsen. Hearing Research . 2018

Outer Hair Cell Molecular Protein, Prestin, as a Serum Biomarker for Hearing Loss: Proof of Concept [J] . Parham Kourosh,Dyhrfjeld-Johnsen Jonas. Otology & Neurotology . 2016 (9)

Activation of the antigen presentation function of mononuclear phagocyte populations associated with the basilar membrane of the cochlea after acoustic overstimulation [J] . W. Yang,R.R. Vethanayagam,Y. Dong,Q. Cai,B.H. Hu. Neuroscience . 2015

Dexamethasone’s Effect in the Retrocochlear Auditory Centers of a Noise-Induced Hearing Loss Mouse Model [J] . Leon Chen,Clare Dean,Michele Gandolfi,Edmund Nahm,Linda Mattiace,Ana H. Kim. Otolaryngology–Head and Neck Surgery . 2014 (4)

Tumor necrosis factor inhibitors: clinical utility in autoimmune diseases [J] . Maria A.V. Willrich,David L. Murray,Melissa R. Snyder. Translational Research . 2014

Inflammation is associated with a worsening of presbycusis: evidence from the MRC national study of hearing. [J] . Verschuur Carl,Agyemang-Prempeh Akosua,Newman Tracey A. International journal of audiology . 2014 (7)

Long-term variability of inflammatory markers and associated factors in a population-based cohort. [J] . Nash Scott D,Cruickshanks Karen J,Klein Ronald,Klein Barbara E K,Nieto F Javier,Chappell Rick,Schubert Carla R,Tsai Michael Y. Journal of the American Geriatrics Society . 2013 (8)

Effects of Hyperbaric Oxygen and Dexamethasone on Proinflammatory Cytokines of Rat Cochlea in Noise-Induced Hearing Loss [J] . Hasan Hüseyin Arslan,Bulent Satar,Muhittin A. Serdar,Mehmet Ozler,Emine Yilmaz. Otology & Neurotology . 2012 (9)

Assessment of neutrophil-lymphocyte ratio in ulcerative colitis: A promising marker in predicting disease severity [J] . Serkan Torun,Bilge Demirel Tunc,Burak Suvak,Hakan Yildiz,Adnan Tas,Abdurrahim Sayilir,Yasemin Ozin Ozderin,Yavuz Beyazit,Ertugrul Kayacetin. Clinics and Research in Hepatology and Gastroenterology . 2012 (5)

Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss [J] . Masuda Masatsugu,Kanzaki Sho,Minami Shujiro,Kikuchi Jun,Kanzaki Jin,Sato Hiroaki,Ogawa Kaoru. Otology & Neurotology . 2012 (7)

Neutrophil-to-lymphocyte ratio associated with mortality in early hepatocellular carcinoma patients after radiofrequency ablation. [J] . Chen Tsung-Ming,Lin Chun-Che,Huang Pi-Teh,Wen Chen-Fan. Journal of gastroenterology and hepatology . 2012 (3)

[Evaluation of neutrophil-lymphocyte ratio usefulness in the diagnosis of appendicitis]. [J] . Bia?as Maciej,Taran Katarzyna,Gryszkiewicz Ma?gorzata,Modzelewski Bogdan. Wiadomosci lekarskie （Warsaw, Poland : 1960） . 2006 (9-10)

Reduction of noise-induced hearing loss using L-NAC and salicylate in the chinchilla. [J] . Kopke R D,Weisskopf P A,Boone J L,Jackson R L,Wester D C,Hoffer M E,Lambert D C,Charon C C,Ding D L,McBride D. Hearing research . 2000 (1-2)

The role of macrophages in the disposal of degeneration products within the organ of corti after acoustic overstimulation. [J] . Fredelius L,Rask-Andersen H. Acta oto-laryngologica . 1990 (1-2)

[J] . .

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

前庭功能在急性低频感音神经性聋的临床特征分析

不同听力曲线类型儿童突发性感音神经性聋预后差异及影响因素分析

孤独症谱系障碍学生社交能力发展支持体系建构个案研究——基于ICF评估系统的融合教育实践

基于婴幼儿有意义听觉整合量表建立并验证婴幼儿听损程度预测模型

远距离与噪声环境下人工耳蜗适配无线调频系统对听障儿童聆听效果的影响