盐酸异丙嗪及盐酸倍他司汀对梅尼埃病的综合应用效果分析

卢肖慧; 季永红; 朱雅丹; 蒋海娇; 张中宝; 付亚峰

doi:10.3969/j.issn.1672-4933.2026.02.011

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盐酸异丙嗪及盐酸倍他司汀对梅尼埃病的综合应用效果分析

临床研究 | 更新时间：2026-07-30

- 盐酸异丙嗪及盐酸倍他司汀对梅尼埃病的综合应用效果分析
- The Comprehensive Application Effect Analysis of Promethazine Hydrochlorine and Betahistine Dihydrochloride on Vertigo
- 中国听力语言康复科学杂志 2026年24卷第2期页码：169-172
- 作者机构：
  
  汕头大学医学院小榄临床学院/中山市小榄人民医院（中山市第五人民医院）中山 528415
- 作者简介：
  
  卢肖慧本科副主任医师；研究方向：耳内科专业
  付亚峰， E-mail：yafeng216249@126.com
- 基金信息：
  
  中山市医学科研项目(2019A020208)
- DOI：10.3969/j.issn.1672-4933.2026.02.011
  中图分类号： R764.3
- 收稿：2025-08-03，
  
  网络首发：2026-03-17，
  
  纸质出版：2026-03-15
- 稿件说明：
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卢肖慧,季永红,朱雅丹等.盐酸异丙嗪及盐酸倍他司汀对梅尼埃病的综合应用效果分析[J].中国听力语言康复科学杂志,2026,24(02):169-172.

LU Xiao-hui,JI Yong-hong,ZHU Ya-dan,et al.The Comprehensive Application Effect Analysis of Promethazine Hydrochlorine and Betahistine Dihydrochloride on Vertigo[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2026,24(02):169-172.
卢肖慧,季永红,朱雅丹等.盐酸异丙嗪及盐酸倍他司汀对梅尼埃病的综合应用效果分析[J].中国听力语言康复科学杂志,2026,24(02):169-172. DOI： 10.3969/j.issn.1672-4933.2026.02.011.

LU Xiao-hui,JI Yong-hong,ZHU Ya-dan,et al.The Comprehensive Application Effect Analysis of Promethazine Hydrochlorine and Betahistine Dihydrochloride on Vertigo[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2026,24(02):169-172. DOI： 10.3969/j.issn.1672-4933.2026.02.011.

摘要

目的

研究盐酸异丙嗪及盐酸倍他司汀对梅尼埃病的疗效，以及对纯音听阈及凝血指标的影响，寻找更具应用价值的治疗方案。

方法

选择2022年1月～2025年5月在我院接受治疗的梅尼埃病患者122例作为研究对象。分为观察组及对照组各61例，两组均需保持卧床休息，确保房间安静昏暗，维持良好的作息时间，放松精神，确保身心愉悦。对照组应用盐酸异丙嗪治疗，观察组在此基础上增加盐酸倍他司汀治疗，治疗2周，对比两组疗效、纯音听阈凝血指标及不良反应。

结果

观察组总有效率96.72%，高于对照组（86.89%）（

＜0.05）。两组治疗前后的纯音听阈差异不显著（

＞0.05）。治疗后两组凝血酶原时间（prothrombin time， PT）和活化部分凝血活酶时间（activated partial thromboplastin time， APTT）水平相对治疗前更高，且观察组显著高于对照组（

＜0.05）。观察组不良反应发生率为13.11%，相对于对照组6.56%，差异不显著（

＞0.05）。

结论

盐酸异丙嗪联合盐酸倍他司汀治疗梅尼埃病患者具有较好的疗效，能优化患者凝血指标，安全性较高，但对纯音听阈无明显影响。

Abstract

Objective

To study the effect of pure sound hearing threshold and coagulation index of promethazine hydrochlorine and betahistine dihydrochloride on vertigo

in order to find treatment plans with more scientific application value.

Methods

122 cases of vertigo treated in our hospital from January 2022 to May 2025 were selected as the study subjects. According to the different treatment method

122 patients were divided into observation group and control group

both groups need to keep bed rest

ensure that the room was quiet and dark

and maintain a good work and rest time

relax the nervous spirit

to ensure physical and mental pleasure. The control group was also treated with promethazine hydrochlorine

and the observation group added betahistine dihydrochloride treatment. The two groups were treated for 2 weeks

the efficacy of the two groups

pure sound hearing threshold before and 2 weeks after treatment

coagulation index

and adverse reactions were compared.

Results

Total response rate in observation group was 96.72%

higher than control group 86.89% (

0.05). The difference between the pure tone hearing threshold before and after the two groups had not significant (

0.05). But Prothrombin time (PT) and activated partial thromboplastin time (APTT) levels were higher in the two groups after treatment than in the control group (

0.05). Overall incidence of adverse effects of observation group 13.11%

and compared with 6.56% of control group

difference had not significant (

0.05).

Conclusion

The combination of promethazine hydrochlorine and betahistine dihydrochloride in treating patients with vertigo has good effect

and can optimize its coagulation index

high safety

but no obvious effect on pure sound hearing threshold.

关键词

Keywords

references

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