阻塞性睡眠呼吸暂停儿童听功能评估及模型构建

邹怡; 陆颖霞; 宇文奇; 张旭

doi:10.3969/j.issn.1672-4933.2025.03.012

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阻塞性睡眠呼吸暂停儿童听功能评估及模型构建

临床研究 | 更新时间：2026-07-11

- 阻塞性睡眠呼吸暂停儿童听功能评估及模型构建
- Assessment of Auditory Function and Predictive Model Construction in Children with Obstructive Sleep Apnea
- 中国听力语言康复科学杂志 2025年23卷第3期页码：276-280
- 作者机构：
  
  1.首都医科大学生物医学工程学院北京 100069
  2.首都医科大学附属首都儿童医学中心北京 100020
- 作者简介：
  
  邹怡硕士在读主管技师；研究方向：小儿听力学
  张旭，E-mail：zhangxu@ccmu.edu.cn
- 基金信息：
- DOI：10.3969/j.issn.1672-4933.2025.03.012
  中图分类号： R764.5
- 收稿：2025-01-24，
  
  纸质出版：2025-05-15
- 稿件说明：
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邹怡,陆颖霞,宇文奇等.阻塞性睡眠呼吸暂停儿童听功能评估及模型构建[J].中国听力语言康复科学杂志,2025,23(03):276-280.

ZOU Yi,LU Ying-xia,YUWEN Qi,et al.Assessment of Auditory Function and Predictive Model Construction in Children with Obstructive Sleep Apnea[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2025,23(03):276-280.
邹怡,陆颖霞,宇文奇等.阻塞性睡眠呼吸暂停儿童听功能评估及模型构建[J].中国听力语言康复科学杂志,2025,23(03):276-280. DOI： 10.3969/j.issn.1672-4933.2025.03.012.

ZOU Yi,LU Ying-xia,YUWEN Qi,et al.Assessment of Auditory Function and Predictive Model Construction in Children with Obstructive Sleep Apnea[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2025,23(03):276-280. DOI： 10.3969/j.issn.1672-4933.2025.03.012.

摘要

目的

通过对阻塞性睡眠呼吸暂停（obstructive sleep apnea，OSA）儿童的听力效果进行评估，建立基于机器学习方法的OSA儿童听力损失预测模型。

方法

选择经多导睡眠监测诊断为OSA的儿童为研究对象，其中轻度组64耳、中重度组96耳。同期体检的健康儿童为对照组，共94耳。对所有受试者进行听功能评估。采用支持向量机、逻辑回归、朴素贝叶斯3种机器学习方法建立OSA儿童听力损失预测模型并选出最优模型。

结果

①3组气导听阈在0.25～2 kHz差异无统计学意义；4 kHz及以上高频和扩展高频差异具有统计学意义（

0.05）。②3组畸变产物耳声发射（DPOAE）幅值在0.75～3 kHz差异无统计学意义；在4、6、8 kHz差异具有统计学意义（

0.05）。③3组ABRⅠ波、Ⅲ波潜伏期及Ⅰ～Ⅲ波间期差异无统计学意义；Ⅴ波潜伏期及Ⅲ～Ⅴ、Ⅰ～Ⅴ波间期差异具有统计学意义（

0.05）。④基于朴素贝叶斯方法构建的OSA儿童听力损失模型为最优预测模型。⑤模型特征重要性排名显示，重要的影响因素为最低血氧饱和度和氧降指数。

结论

儿童OSA与听力损失存在显著关联，低氧血症的严重程度是导致OSA儿童听力损失的关键因素。

Abstract

Objective

This study aims to assess the auditory function in children with obstructive sleep apnea (OSA) and to construct a machine learning-based predictive model for hearing loss in pediatric OSA patients.

Methods

Children diagnosed with OSA through polysomnography (PSG) were enrolled as study subjects

categorized into a mild group (64 ears) and a moderate-to-severe group (96 ears). A control group of 94 ears from healthy children undergoing routine physical examinations during the same period was also included. Comprehensive auditory function assessments were conducted on all the participants. Three machine learning methods:Support Vector Machine

Logistic Regression

and Naive Bayes were employed to construct predictive models for hearing loss in children with OSA. The optimal model was selected based on performance metrics.

Results

①No significant differences were observed in hearing thresholds at 0.25-2 kHz across the three groups. However

significant differences were noted at frequencies ≥4 kHz and in the extended high-frequency range (

0.05).②Distortion product otoacoustic emission (DPOAE) amplitudes showed no significant differences at 0.75-3 kHz but exhibited significant variations at 4

6 and 8 kHz (

0.05).③Auditory brainstem response (ABR) measurements revealed no significant differences in Wave I and III latencies or the I-III interpeak interval. However

significant differences were observed in Wave V latency and the III-V and I-V interpeak intervals (

0.05).④The Naive Bayes-based model demonstrated superior performance in predicting hearing loss in children with OSA.⑤Feature importance analysis identified the lowest oxygen saturation and oxygen desaturation index as the most influential predictors of hearing loss.

Conclusion

This study establishes a significant association between OSA and hearing loss in children

with the severity of hypoxemia emerging as a critical determinant. The Naive Bayes-based predictive model offers a robust tool for identifying hearing loss risk in pediatric OSA patients

highlighting the importance of early intervention and monitoring.

关键词

Keywords

references

中华耳鼻咽喉头颈外科杂志编委会 , 中华医学会耳鼻咽喉科学分会 . 儿童阻塞性睡眠呼吸暂停低通气综合征诊疗指南草案(乌鲁木齐) [J ] . 中华耳鼻咽喉头颈外科杂志 , 2007 , 42 ( 2 ): 83 - 84 .

刘静 , 常丽 , 曹玲 . 儿童阻塞性睡眠呼吸暂停的研究进展 [J ] . 中国医刊 , 2021 , 56 ( 7 ): 717 - 720 .

Chen CK , Shen SC , Lee LA , et al . Idiopathic Sudden Sensorineural Hearing Loss in Patients with Obstructive Sleep Apnea [J ] . Nat Sci Sleep , 2021 , 13 : 1877 - 1885 .

刘康 , 刘稳 , 周鹏 , 等 . 基于不同算法预测模型在阻塞性睡眠呼吸暂停低通气综合征中的比较 [J ] . 中国耳鼻咽喉头颈外科 , 2023 , 30 ( 7 ): 467 - 470 .

Silva GFS , Fagundes TP , Teixeira BC , et al . Machine Learning for Hypertension Prediction: a Systematic Review [J ] . Curr Hypertens Rep , 2022 , 24 ( 11 ): 523 - 533 .

Song X , Liu X , Liu F , et al . Comparison of machine learning and logistic regression models in predicting acute kidney injury: A systematic review and meta-analysis [J ] . Int J Med Inform , 2021 , 151 : 104484 .

Smith LA , Oakden-Rayner L , Bird A , et al . Machine learning and deep learning predictive models for long-term prognosis in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis [J ] . Lancet Digit Health , 2023 , 5 ( 12 ): e872 - e881 .

倪鑫 . 中国儿童阻塞性睡眠呼吸暂停诊断与治疗指南(2020) [J ] . 中国循证医学杂志 , 2020 , 20 ( 8 ): 883 - 900 .

GB/T 16296.1-2018 , 声学测听方法第1部分:纯音气导和骨导测听法 [S ] .

World Health Organization . World report on hearing [R/OL ] . https://www.who.int/publications/i/item/9789240020481.2021-03-03 https://www.who.int/publications/i/item/9789240020481.2021-03-03 .

Emmett SD , Platt A , Gallo JJ , et al . Prevalence of Childhood Hearing Loss in Rural Alaska [J ] . Ear Hear , 2023 , 44 ( 5 ): 1240 - 1250 .

Chopra A , Jung M , Kaplan RC , et al . Sleep Apnea Is Associated with Hearing Impairment: The Hispanic Community Health Study/Study of Latinos [J ] . J Clin Sleep Med , 2016 , 12 ( 5 ): 719 - 726 .

Kasemsuk N , Chayopasakul V , Banhiran W , et al . Obstructive Sleep Apnea and Sensorineural Hearing Loss: A Systematic Review and Meta-analysis [J ] . Otolaryngol Head Neck Surg , 2023 , 169 ( 2 ): 201 - 209 .

Wang C , Xu F , Chen M , et al . Association of Obstructive Sleep Apnea-Hypopnea Syndrome with hearing loss: A systematic review and meta-analysis [J ] . Front Neurol , 2022 , 13 : 1017982 .

Chauhan P , Guleria TC , Sharma S , et al . Obstructive Sleep Apnea and Hearing Loss: Is There Any Correlation? [J ] . Int Arch Otorhinolaryngol , 2022 , 27 ( 3 ): e435 - e439 .

Kayabasi S , Hizli O , Yildirim G . The association between obstructive sleep apnea and hearing loss: a cross-sectional analysis [J ] . Eur Arch Otorhinolaryngol , 2019 , 276 ( 8 ): 2215 - 2221 .

Matsumura E , Matas CG , Sanches SGG , et al . Severe obstructive sleep apnea is associated with cochlear function impairment [J ] . Sleep Breath , 2018 , 22 ( 1 ): 71 - 77 .

Li X , Chen WJ , Zhang XY , et al . Inner ear function in patients with obstructive sleep apnea [J ] . Sleep Breath , 2020 , 24 ( 1 ): 65 - 69 .

Daniel SJ , McIntosh M , Akinpelu OV , et al . Hearing outcome of early postnatal exposure to hypoxia in Sprague-Dawley rats [J ] . Laryngol Otol , 2014 , 128 ( 4 ): 331 - 335 .

Jo YS , Lee JM . Assessing the impact of apnea duration on the relationship between obstructive sleep apnea and hearing loss [J ] . PLoS One , 2024 , 19 ( 12 ): e0315580 .

Vorlová T , Dlouhá O , Kemlink D , et al . Decreased perception of high frequency sound in severe obstructive sleep apnea [J ] . Physiol Res , 2016 , 65 ( 6 ): 959 - 967 .

İriz A , Düzlü M , Köktürk O , et al . The effect of obstructive sleep apnea syndrome on the central auditory system [J ] . Turk J Med Sci , 2018 , 48 ( 1 ): 5 - 9 .

Ficker JH , Feistel H , Möller C , et al . Changes in regional CNS perfusion in obstructive sleep apnea syndrome: initial SPECT studies with injected nocturnal 99mTc-HMPAO [J ] . Pneumologie , 1997 , 51 ( 9 ): 926 - 930 .

Ekin S , Turan M , Arısoy A , et al . Is There a Relationship Between Obstructive Sleep Apnea (OSA) and Hearing Loss? [J ] . Med Sci Monit , 2016 , 22 : 3124 - 3128 .

Chen GD . Effect of hypoxia on noise-induced auditory impairment [J ] . Hearing research , 2002 , 172 ( 1-2 ): 186 - 195 .

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