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SIRT1 基因突变致感音神经性聋的研究及其与年龄的相关性A Study on the Association between
Sirt1 Gene Polymorphism and Age in Sensorineural Hearing Loss- 中国听力语言康复科学杂志 2023年21卷第6期 页码：601-606
- 作者机构：
邯郸市第三医院耳鼻喉科 邯郸 056001
- 作者简介：
梁佳 硕士 主治医师；研究方向：感音神经性聋
张社江，E-mail：1183843631@qq.com
- 基金信息：邯郸市科学技术研究与发展计划项目“经迷路及面隐窝入路透明面神经、鼓索神经人工耳蜗植入术治疗合并共同腔畸形及伴分泌性中耳炎的重度感音神经性聋患者效果研究”(21422083104)
DOI：10.3969/j.issn.1672-4933.2023.06.012
中图分类号：纸质出版日期：2023-11-15，
收稿日期：2023-05-11，
- 稿件说明：
移动端阅览
梁佳,吴琼芳,马宁等.SIRT1基因突变致感音神经性聋的研究及其与年龄的相关性[J].中国听力语言康复科学杂志,2023,21(06):601-606.
LIANG Jia,WU Qiong-fang,MA Ning,et al.A Study on the Association between Sirt1 Gene Polymorphism and Age in Sensorineural Hearing Loss[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2023,21(06):601-606.
梁佳,吴琼芳,马宁等.SIRT1基因突变致感音神经性聋的研究及其与年龄的相关性[J].中国听力语言康复科学杂志,2023,21(06):601-606. DOI： 10.3969/j.issn.1672-4933.2023.06.012.
LIANG Jia,WU Qiong-fang,MA Ning,et al.A Study on the Association between Sirt1 Gene Polymorphism and Age in Sensorineural Hearing Loss[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2023,21(06):601-606. DOI： 10.3969/j.issn.1672-4933.2023.06.012.
摘要
目的
2
探讨不同年龄段人群沉默信息调节因子相关酶1（silent mating type information regulator 1，
SIRT1
）基因多态性与感音神经性聋的相关性。
方法
2
以2021年3月～2022年12月我院就诊的105例感音神经性聋患者为观察组，同期在我院体检的同龄105例健康人群为对照组。根据年龄将观察组分为A组（
<
60岁）和B组（≥60岁），对照组分为C组（
<
60岁）和D组（≥60岁）。对所有患者进行DNA提取和
SIRT1
rs7895833、rs7069102、rs2273773三个位点的基因多态性检测，分析其与感音神经性聋的相关性。
结果
2
（1）观察组和对照组rs2273773、rs7069102基因型/等位基因分布差异无统计学意义（
P
＞0.05）。（2）4个亚组rs2273773、rs7069102基因型/等位基因分布差异无统计学意义（
P
＞0.05）。（3）观察组和对照组rs7895833基因型/等位基因分布差异具有统计学意义，观察组rs7895833 GG型显著高于对照组（
P
<
0.05）。（4）A组和C组rs7895833基因型/等位基因分布差异无统计学意义（
P
>
0.05）；B组和D组rs7895833基因型/等位基因分布差异有统计学意义（
P
<
0.05），B组GG型显著高于D组（
P
<
0.05），等位基因G显著高于D组（
P
<
0.05）。（5）Logistic回归分析显示，对于所有人群，GG型rs7895833基因型人群发生感音神经性聋的风险是AA型rs7895833基因型人群的1.919倍（95%CI：1.299～2.835，
P
<
0.01）；对于≥60岁人群，GG型rs7895833基因型人群发生感音神经性聋的风险是AA型rs7895833基因型人群的2.30倍（95%CI：1.409～3.755，
P
<
0.01）。（6）感音神经性聋患者rs7895833基因型多态性GG型与年龄存在正相关（
r
=0.440，
P
＜0.01）。
结论
2
SIRT1
基因GG基因型与感音神经性聋存在密切关系，是60岁以上老年人群发生感音神经性聋的危险因素。
Abstract
Objective
2
To explore the correlation between polymorphism of silent matching type information regulator 1 (
SIRT1
) gene and sensorineural hearing loss in different age groups.
Methods
2
105 patients with sensorineural hearing loss who visited our hospital from March 2021 to December 2022 were selected as the observation group
while 105 healthy individuals of the same age who underwent physical examination at our hospital were selected as the control group. According to age
the observation group was further divided into Group A (
<
60 years old) and Group B (≥ 60 years old)
while the control group was further divided into Group C (
<
60 years old) and Group D (≥ 60 years old). DNA extraction was performed on all patients
and gene polymorphisms at three loci:
SIRT1
rs7895833
rs7069102
and rs2273773 were detected
and their correlation with sensorineural hearing loss was analyzed.
Result
2
(1) There was no statistically significant difference in the distribution of rs2273773 genotype/allele between the observation group and the control group (
P
>
0.05); There was no statistically significant difference in the genotype/allele distribution of rs7069102 between the observation group and the control group (
P
>
0.05). (2) There was no statistically significant difference in the distribution of rs2273773 genotype/allele and rs7069102 genotype/allele among the four subgroups (
P
>
0.05). (3) There were statistically significant differences in the distribution of rs7895833 genotypes/alleles between the observation group and the control group. The rs7895833 GG genotype in the observation group was significantly higher than that in the control group (
P
<
0.05). (4) There was no statistically significant difference in the genotype/allele distribution of rs7895833 between Group A and Group C (P
>
0.05); There was a statistically significant difference in the genotype/allele distribution of rs7895833 between Group B and Group D (
P
<
0.05). The GG genotype in Group B was significantly higher than that in Group D (
P
<
0.05)
and the allele G was significantly higher than that in Group D (
P
<
0.05). (5) Logistic regression analysis: For all populations
the risk of sensorineural hearing loss in the GG type rs7895833 genotype population is 1.919 times higher than that in the AA type rs7895833 genotype population (95%
CI: 1.299-2.835
P
<
0.01); For individuals ≥ 60 years old
the risk of sensorineural hearing loss in the GG type rs7895833 genotype population is 2.30 times higher than that in the AA type rs7895833 genotype population (95% CI: 1.409-3.755
P
<
0.01). (6) There is a positive correlation between rs7895833 genotype polymorphism and age in patients with sensorineural hearing loss (
r
=0.440
P
<
0.01).
Conclusion
2
The GG genotype of the
SIRT1
gene is closely related to sensorineural hearing loss and is a risk factor for sensorineural hearing loss in the elderly population over 60 years old.
关键词
沉默信息调节因子相关酶1基因多态性感音神经性聋年龄相关性
Keywords
Silent mating type information regulator 1Genetic polymorphismSensorineural hearing lossAgeRelevance
references
Huafeng Y, Hongqin W, Wenna Z, et al. Clinical characteristics and prognosis of elderly patients with idiopathic sudden sensorineural hearing loss[J]. Acta Otolaryngol, 2019 , 139(10):866-869.
陈海军, 孙宗润, 郭岩,等. 感音神经性耳聋分子机制的研究进展[J]. 解剖学杂志, 2021, 44(6): 526-529.
Jakovljevic A, Nikolic N, Jacimovic J, et al. Tumor Necrosis Factor Alpha -308 G/A Single-Nucleotide Polymorphism and Apical Periodontitis: An Updated Systematic Review and Meta-analysis[J]. Journal of endodontics, 2021, 47(7):1061-1069.
Alam F, Rehman R, Fatima SS, et al. Suggested role of Silent Information Regulator 1 (SIRT1) Gene in Female Infertility: A Cross Sectional Study in Pakistan[J]. Int J ClinPract, 2021, 75(6):e14132.
国威, 肖溪, 田裕涛,等. SIRT1基因在抑郁症中的作用及机制研究进展[J]. 生理学报, 2021, 73(5):828-834.
Tao H, Liu Y, Hou Y. miRNA-384-5p regulates the progression of Parkinson's disease by targeting SIRT1 in mice and SH-SY5Y cells[J]. Int J mol med, 2020, 45(2):441-450.
Dong YT, Cao K, Xiang J, et al. Silent Mating-Type Information Regulation 2 Homolog 1 Attenuates the Neurotoxicity Associated with Alzheimer Disease via a Mechanism Which May Involve Regulation of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha[J]. Am Journal Pathol, 2020, 190(7): 1545-1564.
Rodriguez-Miguelez P, Pollock JS . Adverse childhood events and cardiovascular diseases: the potential role of Sirt1[J]. Am J Physiol, 2021, 321(3):577-579.
孙建军. 感音神经性聋的MRI诊断[J]. 国外医学:耳鼻咽喉科学分册, 1994,18(4):213-214.
Emre S, Karlidag T, Aydın S, et al. Can prestin level be a biomarker for determining sensorineural hearing loss? [J]. Auris Nasus Larynx, 2022, 49(3):368-373.
Yang SM, Yeh KC, Pan SL. Increased risk of sensorineural hearing loss in patients with spinal cord injury: a nationwide longitudinal follow-up study[J]. Spinal Cord. 2021, 59(11):1200-1205.
Liao EN, Taketa E, Mohamad NI, et al. Outcomes of Gene Panel Testing for Sensorineural Hearing Loss in a Diverse Patient Cohort[J]. JAMA Netw Open, 2022, 5(9):e2233441.
Wei Z, Chang K, Fan C. Association between the 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene and sudden sensorineural hearing loss in Caucasian population: a meta-analysis[J]. Eur Arch Otorhinolaryngol, 2021, 278(7):2203-2208.
Yan P, Li Z, Xiong J, et al. LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity[J]. Cell Rep, 2021, 37(8):110038.
Xu C, Wang L, Fozouni P, et al. SIRT1 is downregulated by autophagy in senescence and ageing[J]. Nat Cell Biol, 2020, 22(10):1170-1179.
Lee M, Choi S, Lee Y, et al. The Gender Association of the SIRT1 rs7895833 Polymorphism with Pediatric Obesity: A 3-Year Panel Study[J]. J Nutrigenet Nutrigenomics, 2016, 9(5-6):265-275.
Casarotto A, Galera BB, Sumiyoshi LM, et al. Polymorphism rs7895833 in the SIRT1 gene and its association with dyslipidaemia in the elderly[J]. Revista Española de Geriatría y Gerontología, 2019, 54(4):214-219.
Yassin H, Mahmoud S, El-Din SM, et al. The impact of SIRT1 serum level and its gene single nucleotide polymorphism (rs7895833) on the prediction of hepatocellular carcinoma in a cohort of cirrhotic population[J]. Senses and Sciences, 2019, 3(4):33-39.
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