年龄相关性听力损失相关信号通路研究进展

胡俊豪; 李愉; 王珊珊; 洪玉

doi:10.3969/j.issn.1672-4933.2023.04.017

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年龄相关性听力损失相关信号通路研究进展

综述 | 更新时间：2023-07-21

- 年龄相关性听力损失相关信号通路研究进展
- Research Progress of Presbycusis Related Signaling Pathways
- 中国听力语言康复科学杂志 2023年21卷第4期页码：403-407
- 作者机构：
  
  杭州师范大学公共卫生学院杭州 311121
- 作者简介：
  
  胡俊豪硕士；研究方向：蛋白质功能与疾病，环境与疾病的分子机制研究
  洪玉，E-mail：hongyu_xj@126.com
- 基金信息：
- DOI：10.3969/j.issn.1672-4933.2023.04.017
  中图分类号：
- 纸质出版日期：2023-07-15，
  
  收稿日期：2023-04-13，
- 稿件说明：
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胡俊豪,李愉,王珊珊等.年龄相关性听力损失相关信号通路研究进展[J].中国听力语言康复科学杂志,2023,21(04):403-407.

HU Jun-hao,LI Yu,WANG Shan-shan,et al.Research Progress of Presbycusis Related Signaling Pathways[J].Chinese Scientifific Journal of Hearing and Speech Rehabilitation,2023,21(04):403-407.
胡俊豪,李愉,王珊珊等.年龄相关性听力损失相关信号通路研究进展[J].中国听力语言康复科学杂志,2023,21(04):403-407. DOI： 10.3969/j.issn.1672-4933.2023.04.017.

HU Jun-hao,LI Yu,WANG Shan-shan,et al.Research Progress of Presbycusis Related Signaling Pathways[J].Chinese Scientifific Journal of Hearing and Speech Rehabilitation,2023,21(04):403-407. DOI： 10.3969/j.issn.1672-4933.2023.04.017.

摘要

年龄相关性听力损失（age-related hearing loss，ARHL）又称老年性聋（presbycusis），是一种在老年人中普遍存在的慢性疾病，其主要表现为进行性听力下降。氧化应激、细胞凋亡及线粒体功能异常等机制在ARHL发展进程中起重要作用，而其相关信号通路在其中也发挥重要作用。本文对目前研究较多的ARHL相关信号通路进行综述，旨在为进一步探讨ARHL的发病机制提供参考，为寻找新的治疗靶点提供新思路。

Abstract

Age-related hearing loss (ARHL)

also known as Presbycusis

is a common chronic disease in the elderly

mainly manifested by progressive hearing loss. Current research shows that oxidative stress

apoptosis and mitochondrial dysfunction play an important role in the development of ARHL

and its related signal pathways play an important role in it. This article reviews the signal pathways related to ARHL that have been studied extensively at present

in order to provide a reference for further exploring the pathogenesis of ARHL and provide new ideas for finding new therapeutic targets.

关键词

年龄相关性听力损失信号通路氧化应激凋亡

Keywords

Age-related hearing lossPathway of signalOxidative stressApoptosis

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