转化医学在耳科领域中的应用

何玺洁; 王倩; 李世博; 钟时勋; 冀飞

doi:10.3969/j.issn.1672-4933.2023.03.017

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转化医学在耳科领域中的应用

综述 | 更新时间：2023-05-22

- 转化医学在耳科领域中的应用
- Application of Translational Medicine to the Field of Otology
- 中国听力语言康复科学杂志 2023年21卷第3期页码：290-293
- 作者机构：
  
  1.解放军总医院耳鼻咽喉头颈外科医学部/国家耳鼻咽喉疾病临床医学研究中心北京 100853
  2.重庆医科大学附属第一医院重庆 400042
- 作者简介：
  
  何玺洁本科；研究方向：听力与言语康复学
  钟时勋，E-mail：zhongsx@sohu.com
  冀飞，E-mail：argfei301@163.com
- 基金信息：
  
  国家重点研发计划项目(2020YFC2005200);国家耳鼻咽喉疾病临床医学中心开放课题(202200010);2022年首都卫生发展科研专项重点攻关课题(首发2022-1-2023)
- DOI：10.3969/j.issn.1672-4933.2023.03.017
  中图分类号：
- 纸质出版日期：2023-05-15，
  
  收稿日期：2023-03-13，
- 稿件说明：
移动端阅览
何玺洁,王倩,李世博等.转化医学在耳科领域中的应用[J].中国听力语言康复科学杂志,2023,21(03):290-293.

HE Xi-jie,WANG Qian,LI Shi-bo,et al.Application of Translational Medicine to the Field of Otology[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2023,21(03):290-293.
何玺洁,王倩,李世博等.转化医学在耳科领域中的应用[J].中国听力语言康复科学杂志,2023,21(03):290-293. DOI： 10.3969/j.issn.1672-4933.2023.03.017.

HE Xi-jie,WANG Qian,LI Shi-bo,et al.Application of Translational Medicine to the Field of Otology[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2023,21(03):290-293. DOI： 10.3969/j.issn.1672-4933.2023.03.017.

摘要

转化医学是生物—心理—社会医学模式下打破传统藩篱的重要概念，主张以患者为中心，强调多学科合作，其核心是将医学生物学基础研究成果转化为临床实践中应用的理论、技术、方法和药物，实现基础研究和临床研究间的双向转化，提高医疗总体水平。听力障碍是人类常见的残疾之一。本文就转化医学在耳科领域中的应用进行文献综述，介绍了人工耳蜗改进、耳聋基因检测与治疗、内耳药物治疗及药物递送技术、成人听力康复技术，总结现有研究成果、不足及未来方向，对于耳科及听觉科学中基础研究与临床应用的相互转化，下一步发展临床可用的各种类型听力损失的干预和康复技术具有重要意义。

Abstract

Translational medicine is an important concept in the bio-psycho-social medicine model that breaks the traditional barriers

advocates patient-centeredness and emphasizes multidisciplinary cooperation. Its core is to translate the results of basic research in medical biology into theories

technologies

methods and drugs that can be applied in clinical practice

to achieve a two-way translation between basic and clinical research

and to improve the overall level of medical treatment. Hearing impairment is one of the most common human disabilities. In this paper

we present a literature review on the application of translational medicine in the field of otology

and introduce cochlear implant improvement

gene therapy for deafness

inner ear drug therapy and delivery techniques

unilateral hearing loss intervention

and hearing rehabilitation techniques for adults. We summarize existing research results

shortcomings

and future directions

which is of great significance to the next development for clinically available intervention and rehabilitation techniques for various types of hearing loss.

关键词

转化医学耳科听觉科学

Keywords

Translational medicineOtologyAuditory science

references

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