Sensorineural deafness is a common disease caused by dysfunction in one or more parts of the auditory pathway between the inner ear and the auditory cortex

with complex etiologies that include ototoxic drugs

noise exposure and ageing in addition to genetic factors. According to a 2018 WHO study

466 million people worldwide have moderate to severe binaural hearing loss

accounting for approximately 6.1% of the world’s population

and the number of people with hearing impairment is growing year on year and is trending younger. A large body of research evidence suggests that oxidative stress generates excess reactive oxygen radicals as a possible common pathological link in hearing impairment processes including noise deafness

age-related deafness

drug-induced deafness and sudden sensorineural deafness. This study provides a review of the mechanisms of oxidative stress damage in these diseases.