Objective To investigate the effects of home isolation on the neuropsychomotor development of 0-1 year old infants during the epidemic period. Methods A retrospective analysis was conducted on the screening data of neuropsychological development of 0-1-year-old infants who received child health care in the physical examination outpatient department of the Health Center of Beijing Children’s Hospital. The study group was composed of 622 infants from April 1

2020 to August 30

2020

and the control group of 569 infants from April 1

2019 to August 30

2019. Independent sample t test was used to compare and analyze the gross motor

fine motor

adaptive ability

language and social behavior of the two groups of infants. Results There were no significant differences between the study group and the control group in the mean scores of all energy areas except for the gross motor（P=0.323）

and there were differences in the scores of fine motor

adaptability

language ability and social behavior（P<0.05）

among which the mean of fine motor increased

the mean of adaptability

language ability and social behavior decreased

and the mean of average score decreased. There was no significant difference in the incidence of gross motor dysplasia between the study group and the control group（136/62

21.9% vs. 125/569

21.8% P=0.966）

and no significant difference in the incidence of social behavior dysplasia（95/62

15.3%vs. 81/569

14.2%

P=0.647）. The incidence of fine motor dysplasia in the study group（91/62

14.6% vs.112/569

19.9% P<0.05）was lower than that in the control group

and the incidence of adaptive dysplasia（152/62

24.4% vs. 89/569

15.6% P<0.05） was higher than that in the control group. The incidence of abnormal language development（134/62

21.5% vs. 75/569

13.2% P<0.05） was significantly higher than that of control group. Conclusion The effects of home isolation on infants’ neuropsychomotor development mainly lie in the areas of adaptive and language development. Attention should be paid to infants’ social behavior

to reduce adverse factors at home

and to family parenting guidance and intervention follow-up.