老年突发性耳聋患者血管内皮因子水平与内耳微循环及听力损失的相关性

刘土辉; 刘思源; 黄晓星; 徐夏

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老年突发性耳聋患者血管内皮因子水平与内耳微循环及听力损失的相关性

康复教育 | 更新时间：2026-07-12

- 老年突发性耳聋患者血管内皮因子水平与内耳微循环及听力损失的相关性
- Correlation Between Vascular Endothelial Factor Levels and Inner Ear Microcirculation and Hearing Loss in Elderly Patients with Sudden Sensorineural Hearing Loss
- 中国听力语言康复科学杂志 2026年页码：1-6
- 作者机构：
  
  1.广州市增城区中心医院耳鼻喉科广州 511340
  2.南方医院增城院区耳鼻咽喉科广州 510515
  3.南方医科大学南方医院耳鼻喉头颈外科广州 510000
- 作者简介：
  
  刘土辉本科主治医师；研究方向：常见耳鼻喉疾病诊治
  徐夏，E-mail：77493055@qq.com
- 基金信息：
  
  广东省医学科研基金立项项目“老年突发性耳聋患者血管内皮因子水平与内耳微循环及听力损失的相关性研究”(B2021250)
- DOI：
  中图分类号： R764.43+7
- 收稿：2025-04-10，
  
  网络首发：2026-06-22，
- 稿件说明：
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刘土辉,刘思源,黄晓星等.老年突发性耳聋患者血管内皮因子水平与内耳微循环及听力损失的相关性[J].中国听力语言康复科学杂志,

LIU Tu-hui,LIU Si-yuan,HUANG Xiao-xing,et al.Correlation Between Vascular Endothelial Factor Levels and Inner Ear Microcirculation and Hearing Loss in Elderly Patients with Sudden Sensorineural Hearing Loss[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,
刘土辉,刘思源,黄晓星等.老年突发性耳聋患者血管内皮因子水平与内耳微循环及听力损失的相关性[J].中国听力语言康复科学杂志, DOI：10.3969/j.issn.1672-4933...001.

LIU Tu-hui,LIU Si-yuan,HUANG Xiao-xing,et al.Correlation Between Vascular Endothelial Factor Levels and Inner Ear Microcirculation and Hearing Loss in Elderly Patients with Sudden Sensorineural Hearing Loss[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation, DOI：10.3969/j.issn.1672-4933...001.

摘要

目的

探讨老年突发性耳聋患者血管内皮因子水平与内耳微循环及听力损失的相关性。

方法

以2021年3月至2024年6月就诊于我院的老年突发性耳聋患者95例作为研究对象，根据患者听力损失严重程度划分为中度以下听力损失组（n=49）和重度以上听力损失组（n=46）。对比两组患者一般临床资料及疾病特征，测定并对比患者治疗前血管内皮因子［血管内皮生长因子（vascular endothelial growth factor，VEGF）、缺氧诱导因子（hypoxia-inducible factor，HIF）1α、同型半胱氨酸（Hcy）］及内耳微循环指标［可溶性血管细胞黏附分子（soluble vascular cell adhesion molecule，sVCAM）、内皮素（endothelin，ET）］的表达水平差异。通过Spearman相关性检验、单因素及多因素Logistic回归分析评价老年突发性耳聋患者临床特征、血管内皮因子水平与内耳微循环指标与严重听力损失的相关性。

结果

重度以上听力损失组患者平均年龄更高，合并糖尿病（47.8% vs 26.5%，P=0.032）及眩晕的比例显著更高。重度以上听力损失组血清 VEGF、HIF-1α、Hcy、sVCAM及 ET水平均显著高于中度以下听力损失组（

0.001）。Spearman相关性分析显示，上述5项指标均与听力损失严重程度呈正相关（rs=0.431～0.479，

0.001）。多因素 Logistic 回归分析校正年龄、糖尿病等混杂因素后，VEGF（OR=1.342，95% CI：1.064~1.693，

=0.013）、HIF-1α（OR=4.808，95% CI：1.149~6.700，

=0.003）、Hcy（OR=1.546，95% CI：1.021~2.339，

=0.039）、sVCAM（OR=1.097，95% CI：1.0

39~1.158，

0.001）及 ET（OR=1.413，95% CI：1.080~1.849，

=0.012）仍是重度听力损失的独立危险因素。

结论

老年突发性耳聋患者血管内皮损伤及内耳微循环障碍程度与听力损失严重程度密切相关。治疗前检测血清 VEGF、HIF-1α、Hcy、sVCAM及ET水平，可辅助评估病情严重程度，为制订个体化治疗方案提供客观依据。

Abstract

Objective

To explore the relationship between the levels of vascular endothelial factors and the microcirculation of the inner ear in elderly patients with sudden sensorineural hearing loss

as well as its impact on their auditory function.

Methods

95 elderly patients with sudden sensorineural hearing loss were studied at our hospital from March 2021 to June 2024. They were categorized based on the severity of their condition into a mild-to-moderate hearing loss group (n=49) and a severe-to-profound hearing loss group (n=46). A comparison was made between the general clinical profiles and disease characteristics of the two groups. The levels of vascular endothelial factors [vascular endothelial growth factor (VEGF)

hypoxia-inducible factor (HIF) 1α

homocysteine (Hcy)] and inner ear microcirculation indicators [soluble vascular cell adhesion molecule (sVCAM)

endothelin (ET)] were assessed and compared before treatment. The relationship between clinical features

vascular endothelial factor levels

inner ear microcirculation indicators

and the development of severe hearing loss in elderly patients with sudden sensorineural hearing loss was analyzed using Spearman correlation test

as well as univariate and multivariate logistic regression analysis.

Results

Patients in the severe-to-profound hearing loss group had a higher average age

and significantly higher proportions of diabetes mellitus and vertigo. Serum levels of VEGF

HIF-1α

Hcy

sVCAM

and ET in the severe-to-profound hearing loss group were significantly higher than those in the mild-to-moderate hearing loss group (

0.001).

Spearman correlation analysis showed that all five indicators were positively correlated with the severity of hearing loss (rs=0.431-0.479

0.001).After adjusting for confounding factors such as age and diabetes mellitus

multivariate logistic regression analysis showed that VEGF(OR=1.342

95%CI:1.064-1.693

=0.013)

HIF-1α(OR=4.808

95%CI:1.149-6.700

=0.003)

Hcy(OR=1.546

95%CI:1.021-2.339

=0.039)

sVCA(OR=1.097

95%CI:1.039-1.158

0.001)

and ET(OR=1.413

95%CI:1.080-1.849

=0.012) remained independent risk factors for severe hearing loss.

Conclusion

The degree of vascular endothelial injury and inner ear microcirculation disturbance is closely related to the severity of hearing loss in elderly patients with SSNHL. Detection of serum VEGF

HIF-1α

Hcy

sVCAM

and ET levels before treatment can assist in assessing the severity of the disease and provide an objective basis for formulating individualized treatment plans.

关键词

Keywords

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