The Correlation between Laryngopharyngeal Reflux and Vocal Cord Lesions and Their Acoustic Analysis of Voice

HUANG Meng; CHEN Wen-yong

doi:10.3969/j.issn.1672-4933.2026.05.009

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The Correlation between Laryngopharyngeal Reflux and Vocal Cord Lesions and Their Acoustic Analysis of Voice

Clinical Research | 更新时间：2026-10-08

- The Correlation between Laryngopharyngeal Reflux and Vocal Cord Lesions and Their Acoustic Analysis of Voice
- Chinese Scientific Journal of Hearing and Speech Rehabilitation Vol. 24, Issue 5, Pages: 496-500(2026)
- 作者机构：
  
  1.广州中医药大学第二临床医学院广州 510405
  2.广东省中医院耳鼻咽喉头颈外科广州 510120
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1672-4933.2026.05.009
  CLC： R767.92
- Received：29 January 2026，
  
  Revised：2026-03-11，
  
  Accepted：19 April 2026，
  
  Published：15 September 2026
- 稿件说明：
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黄萌,陈文勇.咽喉反流与声带病变的相关性及其嗓音声学分析[J].中国听力语言康复科学杂志,2026,24(05):496-500.

HUANG Meng,CHEN Wen-yong.The Correlation between Laryngopharyngeal Reflux and Vocal Cord Lesions and Their Acoustic Analysis of Voice[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2026,24(05):496-500.
黄萌,陈文勇.咽喉反流与声带病变的相关性及其嗓音声学分析[J].中国听力语言康复科学杂志,2026,24(05):496-500. DOI： 10.3969/j.issn.1672-4933.2026.05.009.

HUANG Meng,CHEN Wen-yong.The Correlation between Laryngopharyngeal Reflux and Vocal Cord Lesions and Their Acoustic Analysis of Voice[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2026,24(05):496-500. DOI： 10.3969/j.issn.1672-4933.2026.05.009.

摘要

目的

探讨咽喉反流（laryngopharyngeal reflux，LPR）在不同性质声带病变（慢性炎症、良性占位、癌前病变）中的患病率差异，分析LPR对嗓音障碍患者声学功能的影响。

方法

纳入533例嗓音障碍患者，依据临床诊断分为炎症组（n=222）、良性组（包括息肉、小结、囊肿、任克水肿、肉芽肿，n=250）及癌前组（声带白斑，n=61）。采用反流症状指数量表（reflux symptom index，RSI）和反流体征评分量表（reflux finding score，RFS）评估LPR情况，应用嗓音分析软件检测记录基频（F

）、基频微扰（jitter）、振幅微扰（shimmer）、最长发声时间（maximum phonation time，MPT）等声学参数及嗓音障碍严重指数（dysphonia severity index，DSI），比较组间及LPR亚组间的差异。

结果

LPR总患病率50.09%（267/533），在3组间呈显著递增趋势，炎症组36.94%（82/222）、良性组58.00%（145/250）、癌前组65.57%（40/61）（

0.001）。嗓音声学分析显示，良性组、癌前组的jitter、shimmer显著高于炎症组，而DSI、MPT显著降低（

0.05）。亚组分析发现，与非LPR相比，良性组、癌前组中LPR阳性者的嗓音损害更严重，两组DSI显著降低，良性组LPR阳性患者jitter、shimmer升高，癌前组LPR阳性患者jitter、shimmer升高，MPT降低，差异具有统计学意义（

0.05）。

结论

LPR与声带占位性病变的发生发展密切相关，其患病率随病变性质的进展显著升高。良性占位病变、癌前病变患者表现为明确的嗓音功能叠加损害，LPR是影响嗓音康复预后的关键可控因素。因此，应对所有嗓音障碍患者进行LPR筛查、嗓音声学检测随访，并对声带良性及癌前病变患者实施针对性LPR评估与管理，以优化嗓音治疗预后。

Abstract

Objective

To investigate the prevalence differences of laryngopharyngeal reflux (LPR) in different types of vocal cord lesions (chronic inflammation

benign lesions

precancerous lesions) and analyze the impact of LPR on acoustic function in patients with voice disorders.

Methods

A total of 533 patients with voice disorders wer

e enrolled and classified into three groups based on clinical diagnosis: inflammatory group (n=222)

benign group (including polyps

nodules

cysts

Riecked's edema

and granulomas

n=250)

and precancerous group (vocal cord leukoplakia

n=61). LPR was assessed using the Reflux Symptom Index (RSI) and Reflux Finding Score (RFS). Acoustic parameters

including fundamental frequency (F

)

Jitter

Shimmer

maximum phonation time (MPT)

and dysphonia severity index (DSI)

were recorded and analyzed using voice analysis software. Differences among groups and within LPR subgroups were compared.

Results

The overall prevalence of LPR was 50.09% (267/533)

showing a significant increasing trend across the three groups: inflammatory group (36.94%

82/222)

benign group (58.00%

145/250)

and precancerous group (65.57%

40/61)

with statistically significant differences (

0.001). Acoustic analysis revealed that the Jitter and Shimmer in the benign and precancerous groups were significantly higher than those in the inflammatory group

while the DSI and MPT was significantly reduced (

0.05). Subgroup analysis revealed that compared with non-LPR cases

LPR-positive individuals in the benign and precancerous groups exhibited more severe vocal impairment

with significantly reduced DSI in both groups. LPR-positive patients in the benign group showed increased Jitter and Shimmer

while those in the precancerous group exhibited elevated Jitter and Shimmer accompanied by reduced MPT

with statistically significant differences (

0.05).

Conclusion

LPR is closely associated with the occurrence and progression of vocal cord lesions

with its prevalence markedly increasing as the lesion nature advances. Patients with vocal cord benign lesions and precancerous lesions demonstrate clear superimposed vocal function impairments

where LPR serves as a key controllable factor influencing vocal recovery prognosis. Therefore

all patients with vocal disorders should undergo LPR screening and acoustic vocal assessment follow-up. Targeted LPR evaluation and management should be implemented for patients with vocal cord benign and precancerous lesions to optimize vocal therapy outcomes.

关键词

Keywords

references

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