Cortical Auditory Evoked Potential Waveform Characteristics and Applications to Miniature pigs

TANG Fei; ZHONG Min-xuan; YANG Chong-ling; GUO Wei-wei; LIU Jun

doi:10.3969/j.issn.1672-4933.2026.01.005

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Cortical Auditory Evoked Potential Waveform Characteristics and Applications to Miniature pigs

The Application of Auditory Evoked Potentials in Cochlear Implantation | 更新时间：2026-07-30

- Cortical Auditory Evoked Potential Waveform Characteristics and Applications to Miniature pigs
- Chinese Scientific Journal of Hearing and Speech Rehabilitation Vol. 24, Issue 1, Pages: 25-28(2026)
- 作者机构：
  
  1.解放军总医院第六医学中心耳鼻咽喉头颈外科医学部/听觉与平衡觉国家重点实验室/国家耳鼻咽喉疾病临床医学研究中心/聋病教育部重点实验室/聋病防治北京市重点实验室北京 100048
  2.解放军总医院第七医学中心耳鼻咽喉头颈外科北京 100700
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1672-4933.2026.01.005
  CLC： R764.04
- Received：01 September 2025，
  
  Online First：09 January 2026，
  
  Published：15 January 2026
- 稿件说明：
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唐菲,钟旻璇,杨崇灵等.听力正常小型猪皮层听觉诱发电位波形特征及应用[J].中国听力语言康复科学杂志,2026,24(01):25-28.

TANG Fei,ZHONG Min-xuan,YANG Chong-ling,et al.Cortical Auditory Evoked Potential Waveform Characteristics and Applications to Miniature pigs[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2026,24(01):25-28.
唐菲,钟旻璇,杨崇灵等.听力正常小型猪皮层听觉诱发电位波形特征及应用[J].中国听力语言康复科学杂志,2026,24(01):25-28. DOI： 10.3969/j.issn.1672-4933.2026.01.005.

TANG Fei,ZHONG Min-xuan,YANG Chong-ling,et al.Cortical Auditory Evoked Potential Waveform Characteristics and Applications to Miniature pigs[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2026,24(01):25-28. DOI： 10.3969/j.issn.1672-4933.2026.01.005.

摘要

目的

探讨小型猪皮层听觉诱发电位（cortical auditory evoked potential， CAEP）的波形特征，评估其在听觉皮层功能与可塑性研究中的应用价值。

方法

选取25只健康巴马小型猪，以双耳听力正常为对象，在麻醉状态下采用Smart EP听觉诱发电位系统记录CAEP的外源性成分（P1-N1-P2）和内源性成分失匹配负波（mismatch negativity，MMN），分析其潜伏期和振幅。

结果

25只小型猪中，22只小型猪（44耳）ABR阈值均≤45 dB SPL，所有受试耳均成功引出P1-N1-P2复合波及MMN波，平均潜伏期分别为P1：40.48±11.72 ms， N1：85.20±17.42 ms，P2：127.00±24.81 ms，MMN：213.27±47.86 ms；平均振幅分别为P1-N1：2.04±1.17 μV，N1-P2：1.70±0.90 μV，MMN：1.43±1.15 μV。

结论

小型猪CAEP潜伏期特征较传统啮齿类更接近人类，提示其具有与人类相似的听觉辨别与皮层处理机制，适用于听觉皮层功能、发育及可塑性研究。

Abstract

Objective

To investigate the waveforms of cortical auditory evoked potential (CAEP) in miniature pigs and evaluate their utility for studying auditory cortex function and plasticity.

Methods

Twenty-five healthy Bama miniature pigs were screened

and those with normal hearing in both ears were enrolled. Under anesthesia

CAEP components-exogenous (P1-N1-P2) and endogenous (mismatch negativity

MMN)-were recorded using the Smart EP auditory evoked potential system. Latencies and amplitudes were analyzed.

Results

Of the 25 pigs

22 (44 ears) exhibited ABR thresholds≤45 dB SPL. Both P1-N1-P2 complexes and MMN were reliably elicited in all 44 ears. Mean latencies were: P1 40.48±11.72ms

N1 85.20±17.42ms

P2 127.00±24.81ms

and MMN 213.27±47.86ms. Mean amplitudes were: P1-N1 2.04±1.17µV

N1-P2 1.70±0.90µV

and MMN 1.43±1.15µV.

Conclusion

The latency characteristics of CAEP waveforms in miniature pigs are closer to humans than those in traditional rodent models

suggesting that they may possess auditory discrimination abilities and cortical processing mechanisms similar to humans. Therefore

they can serve as a valuable model for research on auditory cortex function

development

and plasticity.

关键词

Keywords

references

Davis PA . Effects of acoustic stimuli on the waking human brain [J ] . Journal of Neurophysiology , 1939 , 2 ( 6 ): 494 - 499 .

刘军 . 人工耳蜗植入术前耳蜗神经及后通路功能评估 [J ] . 中国听力语言康复科学杂志 , 2023 , 21 ( 5 ): 449 - 455 .

Lightfoot G , Kennedy V . Cortical electric response audiometry hearing threshold estimation: accuracy, speed, and the effects of stimulus presentation features [J ] . Ear & Hearing , 2006 , 27 ( 5 ): 443 - 456 .

谢宇非 , 潘滔 , 鲁兆毅 , 等 . 皮层听觉诱发电位在人工耳蜗植入中的应用 [J ] . 中华耳科学杂志 , 2023 , 21 ( 4 ): 580 - 584 .

Guo W , Yi H , Yan Z , et al . The morphological and functional development of the stria vascularis in miniature pigs [J ] . Reproduction, fertility, and development , 2017 , 29 ( 3 ): 585 - 593 .

唐菲 , 杨崇灵 , 刘军 , 等 . 不同年龄小型猪听觉失匹配负波的波形特征分析 [J ] . 中华耳科学杂志 , 2025 , 23 ( 2 ): 256 - 260 .

谢雅芳 , 马龙 , 赵立东 , 等 . 小型猪与人类听性脑干电位的特性比较 [J ] . 中华耳科学杂志 , 2014 , 12 ( 3 ): 485 - 489 .

Guo W , Yi H , Ren L , et al . The morphology and electrophysiology of the cochlea of the miniature pig [J ] . Anatomical Record Advances in Integrative Anatomy & Evolutionary Biology , 2015 , 298 ( 3 ): 494 - 500 .

Oeur RA , Margulies SS . Target detection in healthy 4-week-old piglets from a passive two-tone auditory oddball paradigm [J ] . BMC Neuroscience , 2020 , 21 ( 1 ): 52 .

Tervaniemi M , Schröger E , Näätänen R . Pre-attentive processing of spectrally complex sounds with asynchronous onsets: an event-related potential study with human subjects [J ] . Neuroscience Letters , 1997 , 227 ( 3 ): 197 - 200 .

Lightfoot G . Summary of the N1-P2 cortical auditory evoked potential to estimate the auditory threshold in adults [J ] . Seminars in Hearing , 2016 , 37 ( 1 ): 1 - 8 .

Wunderlich JL , Cone-Wesson BK . Maturation of CAEP in infants and children: a review [J ] . Hearing Research , 2006 , 212 ( 1-2 ): 212 - 223 .

Pincze Z , Lakatos P , Rajkai C , et al . Separation of mismatch negativity and the N1 wave in the auditory cortex of the cat: a topographic study [J ] . Clinical Neurophysiology , 2001 , 112 ( 5 ): 778 - 784 .

Tikhonravov D , Neuvonen T , Pertovaara A , et al . Effects of an NMDA-receptor antagonist MK-801 on an MMN-like response recorded in anesthetized rats [J ] . Brain Research , 2008 , 12 ( 3 ): 97 - 102 .

Gil-Da-Costa R , Stoner GR , Fung R , et al . Nonhuman primate model of schizophrenia using a noninvasive EEG method [J ] . Proceedings of the National Academy of Sciences of the United States of America , 2013 , 110 ( 38 ): 15425 - 15430 .

Harms L , Michie PT , Näätänen R . Criteria for determining whether mismatch responses exist in animal models: Focus on rodents [J ] . Biological Psychology , 2016 , 116 : 28 - 35 .

Csépe V , Karmos G , Molnár M . Evoked potential correlates of stimulus deviance during wakefulness and sleep in cat--animal model of mismatch negativity [J ] . Electroencephalography & Clinical Neurophysiology , 1987 , 66 ( 6 ): 571 - 578 .

Howell TJ , Conduit R , Toukhsati S , et al . Auditory stimulus discrimination recorded in dogs, as indicated by mismatch negativity (MMN) [J ] . Behavioural Processes , 2012 , 89 ( 1 ): 8 - 13 .

Gilley PM , Sharma A , Dorman M , et al . Developmental changes in refractoriness of the cortical auditory evoked potential [J ] . Clinical Neurophysiology , 2005 , 116 ( 3 ): 648 - 657 .

Näätänen R , Gaillard AW , Mäntysalo S . Early selective-attention effect on evoked potential reinterpreted [J ] . Acta Psychol , 1978 , 42 ( 4 ): 313 - 329 .

Näätänen R . Mismatch negativity (MMN) as an index of central auditory system plasticity [J ] . International Journal of Audiology , 2008 , 47 ( S2 ): S16 - S20 .

Lunney JK , Van Goor A , Walker KE , et al . Importance of the pig as a human biomedical model [J ] . Science translational medicine , 2021 , 13 ( 621 ): eabd5758 .

Silva L , Magliaro F , Carvalho A , et al . Cortical maturation of long latency auditory evoked potentials in hearing children: the complex P1-N1-P2-N2 [J ] . CoDAS , 2017 , 29 ( 2 ): e20160216 .

Silva LA , Couto MI , Tsuji RK , et al . Auditory pathways' maturation after cochlear implant via cortical auditory evoked potentials [J ] . Brazilian Journal of Otorhinolaryngology , 2014 , 80 ( 2 ): 131 - 137 .

Berger JI , Gander PE , Kim J , et al . Neural correlates of individual differences in speech-in-noise performance in a large cohort of cochlear implant users [J ] . Ear & Hearing , 2023 , 44 ( 5 ): 1107 - 1120 .

Anu S , Hannah G . Cross-modal re-organization in clinical populations with hearing loss [J ] . Brain Sciences , 2016 , 6 ( 1 ): 4 .

Sharma A , Dorman MF , Spahr AJ . A sensitive period for the development of the central auditory system in children with cochlear implants: implications for age of implantation [J ] . Ear & Hearing , 2002 , 23 ( 6 ): 532 - 539 .

Fernandes NM , Gil D , Azevedo MF . Mismatch negativity in children with cochlear implant [J ] . International Archives of Otorhinolaryngology , 2019 , 23 ( 3 ): e292 - e298 .

Wang ZJ , Pan T , Ma FR . The effect of auditory stimulation on the development of auditory function [J ] . Journal of Clinical Otorhinolaryngology Head & Neck Surgery , 2016 , 30 ( 12 ): 994 - 997 .

朱斌 , 孟子珅 , 胡萍萍 , 等 . 正常听力儿童及青年失匹配负波研究 [J ] . 听力学及言语疾病杂志 , 2021 , 29 ( 1 ): 25 - 28 .

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