A Study on the Association Between the Risk of Recurrence and Vitamin D Levels after Vestibular Function Rehabilitation in Patients with Otolithiasis

HUANG Xing; WANG Xu-ping; ZHANG Hai-qing; LIU Jin-mei; WANG Lu

doi:10.3969/j.issn.1672-4933.2025.05.008

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A Study on the Association Between the Risk of Recurrence and Vitamin D Levels after Vestibular Function Rehabilitation in Patients with Otolithiasis

Clinical Research | 更新时间：2026-07-30

- A Study on the Association Between the Risk of Recurrence and Vitamin D Levels after Vestibular Function Rehabilitation in Patients with Otolithiasis
- Chinese Scientific Journal of Hearing and Speech Rehabilitation Vol. 23, Issue 5, Pages: 480-486(2025)
- 作者机构：
  
  江苏泰康仙林鼓楼医院耳鼻咽喉头颈外科南京 210023
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1672-4933.2025.05.008
  CLC： R764.3
- Received：09 December 2024，
  
  Online First：11 September 2025，
  
  Published：15 September 2025
- 稿件说明：
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黄星,王旭平,张海庆等.耳石症患者前庭功能康复后复发风险与维生素D水平的相关性研究[J].中国听力语言康复科学杂志,2025,23(05):480-486.

HUANG Xing,WANG Xu-ping,ZHANG Hai-qing,et al.A Study on the Association Between the Risk of Recurrence and Vitamin D Levels after Vestibular Function Rehabilitation in Patients with Otolithiasis[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2025,23(05):480-486.
黄星,王旭平,张海庆等.耳石症患者前庭功能康复后复发风险与维生素D水平的相关性研究[J].中国听力语言康复科学杂志,2025,23(05):480-486. DOI： 10.3969/j.issn.1672-4933.2025.05.008.

HUANG Xing,WANG Xu-ping,ZHANG Hai-qing,et al.A Study on the Association Between the Risk of Recurrence and Vitamin D Levels after Vestibular Function Rehabilitation in Patients with Otolithiasis[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2025,23(05):480-486. DOI： 10.3969/j.issn.1672-4933.2025.05.008.

摘要

目的

观察耳石症（benign paroxysmal positional vertigo，BPPV）患者康复后维生素D水平变化，探究其前庭功能康复后复发风险与维生素D水平的相关性。

方法

对我院诊断为耳石症的283例患者进行康复治疗。根据患者康复前血清中维生素D含量和康复后复发情况分组，收集不同分组患者的一般临床资料、生化指标及评分情况，使用视觉形象失调简表（visual spatial skills short form，VSS-SF）、视觉空间指数评分（visual spatial index，VSI）和伯氏平衡量表（berg balance scale，BBS）对耳石症患者的眩晕情况、前庭症状指数及平衡能力进行评分。分层回归分析耳石症患者不同评分系统与维生素D水平的关系。采用多因素logistic回归分析、限制性立方样条模型及生存曲线分析维生素D水平与BPPV复发风险的相关性。采用

值法对影响耳石症患者前庭功能康复后复发的因素进行敏感性分析。

结果

维生素D缺乏组、维生素D不足组及维生素D充足组在VSI、VSS-SF和BBS评分中具有统计学意义（

0.05）。VSI、VSS-SF及BBS评分与维生素D水平呈负相关关系，随着维生素水平的降低，VSI、VSS-SF及BBS评分均有所上升。复发组和未复发组在血清维生素D含量、高血压、糖尿病、高血脂症、VSI、VSS-SF和BBS评分方面具有统计学意义（

0.05）。随着维生素D的缺乏程度增加，患者复发率随之上升，且维生素D缺乏组复发率显著高于维生素D不足和充足组，高血压、糖尿病、高血脂症也可增加患者复发风险。

结论

BPPV患者维生素D水平的降低可影响前庭功能指标，提高患者复发风险，高血压、糖尿病、高血脂症是影响患者康复后复发的风险因素。

Abstract

Objective

To observe the changes of vitamin D levels in patients with Benign Paroxysmal Positional Vertigo (BPPV) after rehabilitation

and to explore the correlation between the risk of recurrence and vitamin D levels after anterior hall functional recovery in patients with otolithiasis.

Methods

Rehabilitation treatments were provided to 283 patients diagnosed with otolithiasis in our hospital. The patients were grouped according to the serum vitamin D content before recovery and the recurrence after recovery

and the general clinical data

biochemical indexes and scores of the patients in different groups were collected. BBS to score vertigo

vestibular symptom index

and balance in patients with otolithiasis. Stratified regression analysis was performed to analyze the relationship between different scoring systems and vitamin D levels in patients with otolithiasis. Multivariate logistic regression analysis

restrictive cubic spline model and survival curve were used to analyze the association between vitamin D level and the risk of BPPV recurrence. The E-value method was used to analyze the sensitivity of the factors affecting the recurrence of vestibular function after rehabilitation in patients with otolithiasis.

Results

There were statistically significant scores in the vitamin D deficiency group

vitamin D deficiency group

and vitamin D adequacy group in VSI score

VSS-SF score and BBS score (

0.05). VSI score

VSS-SF score and BBS score were negatively correlated with vitamin D level

and with the decrease of vitamin level

VSI score

VSS-SF score and BBS score increased. There were statistically significant levels of serum vitamin D content

hypertension

diabetes mellitus

hyperlipidemia

VSI score

VSS-SF score and BBS score in the recurrence group and the non-recurrence group (

0.05). With the increase of vitamin D defici

ency

the recurrence rate of patients increased

and the recurrence rate of vitamin D deficiency group was significantly higher than that of vitamin D deficiency and vitamin D adequacy group

and hypertension

diabetes mellitus

and hyperlipidemia could also increase the risk of recurrence.

Conclusions

This study has found that the decrease of vitamin D level in patients with BPPV can affect the indicators of vestibular function and increase the risk of recurrence

and hypertension

diabetes mellitus

and hyperlipidemia are also risk factors for recurrence after recovery.

关键词

Keywords

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