Study on Rehabilitation Biomarkers for Long-term Sound Therapy in Tinnitus

GONG Qin; CHEN Huan; WANG Hui-min; LI Xin; JI Fei; YANG Hua; YI Hai-jin

doi:10.3969/j.issn.1672-4933.2025.04.003

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Study on Rehabilitation Biomarkers for Long-term Sound Therapy in Tinnitus

Tinnitus research | 更新时间：2026-07-11

- Study on Rehabilitation Biomarkers for Long-term Sound Therapy in Tinnitus
- Chinese Scientific Journal of Hearing and Speech Rehabilitation Vol. 23, Issue 4, Pages: 352-359(2025)
- 作者机构：
  
  1.清华大学生物医学工程学院北京 100084
  2.安徽工程大学电气工程学院安徽 241000
  3.北京清华长庚医院耳鼻咽喉头颈外科北京 102218
  4.解放军总医院第六医学中心耳鼻咽喉头颈外科医学部北京 100039
  5.北京协和医院北京 100730
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1672-4933.2025.04.003
  CLC： R764.45
- Received：21 March 2025，
  
  Published：15 July 2025
- 稿件说明：
移动端阅览
宫琴,陈欢,王慧敏等.耳鸣长期声治疗康复标志物探究[J].中国听力语言康复科学杂志,2025,23(04):352-359.

GONG Qin,CHEN Huan,WANG Hui-min,et al.Study on Rehabilitation Biomarkers for Long-term Sound Therapy in Tinnitus[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2025,23(04):352-359.
宫琴,陈欢,王慧敏等.耳鸣长期声治疗康复标志物探究[J].中国听力语言康复科学杂志,2025,23(04):352-359. DOI： 10.3969/j.issn.1672-4933.2025.04.003.

GONG Qin,CHEN Huan,WANG Hui-min,et al.Study on Rehabilitation Biomarkers for Long-term Sound Therapy in Tinnitus[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2025,23(04):352-359. DOI： 10.3969/j.issn.1672-4933.2025.04.003.

摘要

目的

探究个性化切迹掩蔽音乐疗法（tailor-made notched-masking music training，TNMMT）对主观性耳鸣长期治疗的有效性和客观定量的康复标志物，为客观定量评估耳鸣干预疗效提供科学依据。

方法

采用多中心研究的方法，涵盖多家医疗机构的主观性耳鸣患者。收集耳鸣患者第0、2、4、8周的行为学、主观量表和静息态脑电数据。

结果

主观性耳鸣患者经过8周TNMMT长期干预治疗后，耳鸣致残量表（tinnitus handicap inventory，THI）、耳鸣功能指数量表（tinnitus functional index，TFI）、视觉模拟量表（visual analogue scale，VAS）量表评分显著降低（

0.05）。耳鸣阈上响度显著降低（

0.05）。第2、4、8周静息态脑电功率谱数据与治疗前第0周相比，Delta波的功率谱密度呈现显著差异（

0.05）；此外，Theta波的功率谱在第0周与第2周、第0周与第8周也存在显著差异（

0.05）。按脑区进一步分析，受试者Delta波在额叶、左颞叶及顶叶区以及Theta波在左额叶、右颞叶和左中央区功率谱密度的变化显著（

0.05）。耳鸣量表与脑电功率谱的相关性分析结果显示，THI、TFI和VAS量表与Delta波的功率谱存在显著负相关。VAS_L评分与Delta波在右顶叶区呈现显著相关（

0.05），TFI与Delta波在左额叶区呈现显著相关（

0.05）。

结论

TNMMT在对主观性耳鸣长期干预治疗中有效，其干预过程中有神经可塑性现象的发生，Delta波功率谱密度与主观量表呈现相关性。

Abstract

Objective

To investigate the long-term efficacy of Tailor-made Notched-Masking Music Training (TNMMT) in treating subjective tinnitus and to identify objective quantitative biomarkers for rehabilitation

providing a scientific basis for objective evaluation of tinnitus and therapeutic outcomes.

Methods

A multicenter study involving subjective tinnitus patients was conducted. Behavioral data

subjective tinnitus scales

and resting-state electroencephalogram (EEG) data were collected at weeks 0

and 8 of TNMMT treatment.

Results

After 8 weeks of TNMMT intervention

subjective tinnitus patients showed significant

reductions in Tinnitus Handicap Inventory (THI)

Tinnitus Functional Index (TFI)

and Visual Analogue Scale (VAS) scores (

0.05). Over-threshold loudness of tinnitus also decreased significantly (

0.05). Compared the baseline (week 0)

resting-state EEG power spectra at weeks 2

and 8 revealed significant differences in Delta wave power spectral density (

0.05)

Additionally

Theta wave power spectra exhibited significant differences between week 0 and weeks 2/8 (

0.05). Regional analysis indicated significant changes in Delta wave power in the frontal

left temporal

and parietal lobes

as well as Theta wave power in the left frontal

right temporal

and left central regions. Correlation analysis demonstrated significant negative associations between THI

TFI

and VAS scores with Delta wave power. Specifically

VAS_L scores correlated significantly with Delta wave power in the right parietal lobe (

0.05)

and TFI scores correlated with Delta power in the left frontal lobe (

0.05).

Conclusion

The TNMMT demonstrates efficacy in long-term intervention for subjective tinnitus

with neuroplasticity phenomena observed during the treatment. Significant correlations were identified between delta band power spectral density and subjective rating scales.

关键词

Keywords

references

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