Research Progress in Early Diagnosis of Autism

ZHAO Fei-yan; WANG Xiao-yan; ZHANG Ping

doi:10.3969/j.issn.1672-4933.2025.03.014

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Research Progress in Early Diagnosis of Autism

Review | 更新时间：2025-05-12

- Research Progress in Early Diagnosis of Autism
- Chinese Scientific Journal of Hearing and Speech Rehabilitation Vol. 23, Issue 3, Pages: 287-289(2025)
- 作者机构：
  
  1.武汉科技大学湖北省妇幼保健院联合培养基地武汉 430070
  2.湖北省妇幼保健院武汉 430070
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1672-4933.2025.03.014
  CLC： G766
- Received：04 March 2024，
  
  Published：15 May 2025
- 稿件说明：
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赵飞燕,王小燕,张萍.孤独症谱系障碍早期诊断的研究进展[J].中国听力语言康复科学杂志,2025,23(03):287-289.

ZHAO Fei-yan,WANG Xiao-yan,ZHANG Ping.Research Progress in Early Diagnosis of Autism[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2025,23(03):287-289.
赵飞燕,王小燕,张萍.孤独症谱系障碍早期诊断的研究进展[J].中国听力语言康复科学杂志,2025,23(03):287-289. DOI： 10.3969/j.issn.1672-4933.2025.03.014.

ZHAO Fei-yan,WANG Xiao-yan,ZHANG Ping.Research Progress in Early Diagnosis of Autism[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2025,23(03):287-289. DOI： 10.3969/j.issn.1672-4933.2025.03.014.

摘要

孤独症谱系障碍（ASD）是一种神经精神类疾病，其核心症状是社会沟通与交往能力缺乏，以及刻板和重复性行为。近年来，除了对大脑发育早期阶段的磁共振成像异常和特定神经电生理标志物的关注外，学者开始探讨综合利用生物标志物形成ASD早期诊断的联合模型旨在为ASD的早期检测提供更多诊断线索，并对患者的预后产生积极影响。

Abstract

Autism Spectrum Disorder (ASD) is widely recognized as a neurological and psychiatric disorder

characterized by a lack of social communication and interaction skills

as well as stereotyped and repetitive behaviors. In recent years

in addition to paying attention to magnetic resonance imaging abnormalities and specific neurophysiological markers in the early stages of brain development

scholars have also begun to explore the comprehensive use of these biomarkers to form a joint model for early diagnosis of ASD. The in-depth research in this direction aims to provide more diagnostic clues for early detection of ASD and have a positive impact on the prognosis of patients.

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references

Maenner MJ , Warren Z , Williams AR , et al . Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2020 [J ] . Morbidity and mortality weekly report Surveillance summaries (Washington , DC: 2002 ), 2023 , 72 ( 2 ): 1 - 14 .

Zhou H , Xu X , Yan W , et al . Prevalence of Autism Spectrum Disorder in China: A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years [J ] . Neuroscience bulletin , 2020 , 36 ( 9 ): 961 - 971 .

Rojas V , Rivera A , Nilo N . Update in diagnosis and early intervention of Autistic Spectrum Disorder [J ] . Revista chilena de pediatria , 2019 , 90 ( 5 ): 478 - 484 .

Skellern CY , Rogers Y , O'Callaghan MJ . A parent-completed developmental questionnaire: follow up of ex-premature infants [J ] . Journal of paediatrics and child health , 2001 , 37 ( 2 ): 125 - 129 .

Hazlett HC , Poe M , Gerig G , et al . Magnetic resonance imaging and head circumference study of brain size in autism: birth through age 2 years [J ] . Archives of general psychiatry , 2005 , 62 ( 12 ): 1366 - 1376 .

Hazlett HC , Gu H , Munsell BC , et al . Early brain development in infants at high risk for autism spectrum disorder [J ] . Nature , 2017 , 542 ( 7641 ): 348 - 351 .

白芝兰 , 戚威 , 张晓娜 , 等 . 孤独症患儿胼胝体磁共振形态及扩散张量成像 [J ] . 中国医学影像技术 , 2010 , 26 ( 5 ): 825 - 827 .

Minnigulova A , Davydova E , Pereverzeva D , et al . Corpus callosum organization and its implication to core and co-occurring symptoms of Autism Spectrum Disorder [J ] . Brain structure & function , 2023 , 228 ( 3-4 ): 775 - 785 .

Kirkovski M , Singh M , Dhollander T , et al . An Investigation of Age-related Neuropathophysiology in Autism Spectrum Disorder Using Fixel-based Analysis of Corpus Callosum White Matter Micro- and Macrostructure [J ] . Journal of Autism and Developmental Disorders , 2024 , 54 ( 6 ): 2198 - 2210 .

陈韵 , 蔡金华 , 刘晓 , 等 . 小年龄段孤独症谱系障碍的脑白质纤维束弥散张量成像研究 [J ] . 重庆医科大学学报 , 2015 , 40 ( 12 ): 1528 - 1532 .

Lewis JD , Evans AC , Jr Pruett JR , et al . The Emergence of Network Inefficiencies in Infants With Autism Spectrum Disorder [J ] . Biol Psychiatry , 2017 , 82 ( 3 ): 176 - 185 .

Chaddad A , Desrosiers C , Hassan L , et al . Hippocampus and amygdala radiomic biomarkers for the study of autism spectrum disorder [J ] . BMC neuroscience , 2017 , 18 ( 1 ): 52 - 52 .

Shen MD , Nordahl CW , Young GS , et al . Early brain enlargement and elevated extra-axial fluid in infants who develop autism spectrum disorder [J ] . Brain : a journal of neurology , 2013 , 136 ( Pt 9 ): 2825 - 2835 .

Shen MD , Kim SH , Mckinstry RC , et al . Increased Extra-axial Cerebrospinal Fluid in High-Risk Infants Who Later Develop Autism [J ] . Biological psychiatry , 2017 , 82 ( 3 ): 186 - 193 .

Shen MD , Nordahl CW , Li DD , et al . Extra-axial cerebrospinal fluid in high-risk and normal-risk children with autism aged 2-4 years: a case-control study [J ] . The lancet Psychiatry , 2018 , 5 ( 11 ): 895 - 904 .

杨艳晓 , 衣明纪 , 单延春 . 孤独症谱系障碍儿童脑电图特点与智力结构分析 [J ] . 临床医药文献电子杂志 , 2020 , 7 ( 43 ): 197 - 198 .

Dawson G , Rieder AD , Johnson MH . Prediction of autism in infants: progress and challenges [J ] . The Lancet Neurology , 2023 , 22 ( 3 ): 244 - 254 .

Wilkinson CL , Gabard-durnam LJ , Kapur K , et al . Use of longitudinal EEG measures in estimating language development in infants with and without familial risk for autism spectrum disorder [J ] . Neurobiology of language (Cambridge, Mass) , 2020 , 1 ( 1 ): 33 - 53 .

Gabard-durnam LJ , Wilkinson C , Kapur K , et al . Longitudinal EEG power in the first postnatal year differentiates autism outcomes [J ] . Nature communications , 2019 , 10 ( 1 ): 4188 .

Santos M , Marques C , Nóbrega PA , et al . Autism spectrum disorders and the amplitude of auditory brainstem response wave I [J ] . Autism research : official journal of the International Society for Autism Research , 2017 , 10 ( 7 ): 1300 - 1305 .

Li A , Gao G , Fu T , et al . Continued development of auditory ability in autism spectrum disorder children: A clinical study on click-evoked auditory brainstem response [J ] . International journal of pediatric otorhinolaryngology , 2020 , 138 : 110305 .

吴荣琴 , 张少觐 , 张广岐 , 等 . 脑干听觉反应(ABR)在青少年精神分裂症和孤独症中的应用 [J ] . 现代电生理学杂志 , 2010 , 17 ( 2 ): 74 - 76 .

Magliaro FC , Scheuer CI , Assumpção Júnior FB , et al . Study of auditory evoked potentials in autism [J ] . Pro-fono:revista de atualizacao cientifica , 2010 , 22 ( 1 ): 31 - 36 .

桑鑫泉 , 李多多 , 朱凤莲 . 脑干听觉诱发电位在孤独症谱系障碍患儿早期诊断中的应用 [J ] . 临床研究 , 2023 , 31 ( 4 ): 15 - 18 .

Miron O , Ari-even roth D , Gabis LV , et al . Prolonged auditory brainstem responses in infants with autism [J ] . Autism research : official journal of the International Society for Autism Research , 2016 , 9 ( 6 ): 689 - 695 .

罗兰 , 汪鸿 , 金正江 , 等 . 孤独症谱系障碍患儿婴儿期体格、神经心理发育及脑干听觉诱发电位特征 [J ] . 临床精神医学杂志 , 2022 , 32 ( 1 ): 17 - 20 .

Blanco B , Lloyd-fox S , Begum-ali J , et al . Cortical responses to social stimuli in infants at elevated likelihood of ASD and/or ADHD: A prospective cross-condition fNIRS study [J ] . Cortex ; a journal devoted to the st udy of the nervous system and behavior, 2023 , 169 : 18 - 34 .

Lloyd-fox S , Blasi A , Pasco G , et al . Cortical responses before 6 months of life associate with later autism [J ] . The European journal of neuroscience , 2018 , 47 ( 6 ): 736 - 749 .

Braukmann , Lloyd-fox S , Blasi A , et al . Diminished socially selective neural processing in 5-month-old infants at high familial risk of autism [J ] . The European journal of neuroscience , 2018 , 47 ( 6 ): 720 - 728 .

邹丹 , 刘海莲 , 黄美容 , 等 . 孤独症谱系障碍患儿血清甘丙肽、神经丝轻链水平与病情严重程度的相关性研究 [J ] . 中国妇幼健康研究 , 2023 , 34 ( 12 ): 52 - 56 .

汪鸿 , 王小燕 , 吴梅荣 , 等 . 孤独症谱系障碍儿童外周血淀粉酶样前体蛋白及脑源性生长因子的特异性研究 [J ] . 中国儿童保健杂志 , 2018 , 26 ( 10 ): 1133 - 1136 .

Lochman I , Švachová V , Mílková PK , et al . Serum Cytokine and Growth Factor Levels in Children with Autism Spectrum Disorder [J ] . Medical science monitor: international medical journal of experimental and clinical research , 2018 , 24 : 2639 - 2646 .

Burstein O , Geva R . The Brainstem-Informed Autism Framework: Early Life Neurobehavioral Markers [J ] . Frontiers in integrative neuroscience , 2021 , 15 : 759614 .

Wang X , Carroll X , Wang H , et al . Prediction of Delayed Neurodevelopment in Infants Using Brainstem Auditory Evoked Potentials and the Bayley II Scales [J ] . Frontiers in pediatrics , 2020 , 8 : 485 - 485 .

Sun B , Wang B , Wei Z , et al . Identification of diagnostic markers for ASD: a restrictive interest analysis based on EEG combined with eye tracking [J ] . Frontiers in neuroscience , 2023 , 17 : 1236637 .

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