Research Progress on Neuroelectrophysiological Evaluation Methods of Auditory Cortex Function

ZHONG Min-xuan; YANG Chong-ling; TANG Fei; GUO Wei-wei; LV Ping; LIU Jun

doi:10.3969/j.issn.1672-4933.2025.01.025

您当前的位置：

首页 >

文章列表页 >

Research Progress on Neuroelectrophysiological Evaluation Methods of Auditory Cortex Function

Post Education | 更新时间：2026-07-11

- Research Progress on Neuroelectrophysiological Evaluation Methods of Auditory Cortex Function
- Chinese Scientific Journal of Hearing and Speech Rehabilitation Vol. 23, Issue 1, Pages: 104-108(2025)
- 作者机构：
  
  1.川北医学院/川北医学院附属医院耳鼻咽喉头颈外科南充 637000
  2.解放军总医院第六医学中心耳鼻咽喉头颈外科医学部/听觉与平衡觉全国重点实验室/国家耳鼻咽喉疾病临床医学研究中心/聋病教育部重点实验室北京 100048
  3.解放军总医院第七医学中心耳鼻咽喉头颈外科北京 100700
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1672-4933.2025.01.025
  CLC： R764
- Received：24 November 2024，
  
  Published：15 January 2025
- 稿件说明：
移动端阅览
钟旻璇,杨崇灵,唐菲等.听皮层功能的神经电生理学评估方法研究进展[J].中国听力语言康复科学杂志,2025,23(01):104-108.

ZHONG Min-xuan,YANG Chong-ling,TANG Fei,et al.Research Progress on Neuroelectrophysiological Evaluation Methods of Auditory Cortex Function[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2025,23(01):104-108.
钟旻璇,杨崇灵,唐菲等.听皮层功能的神经电生理学评估方法研究进展[J].中国听力语言康复科学杂志,2025,23(01):104-108. DOI： 10.3969/j.issn.1672-4933.2025.01.025.

ZHONG Min-xuan,YANG Chong-ling,TANG Fei,et al.Research Progress on Neuroelectrophysiological Evaluation Methods of Auditory Cortex Function[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2025,23(01):104-108. DOI： 10.3969/j.issn.1672-4933.2025.01.025.

摘要

植入年龄和听觉剥夺时间是影响先天性聋患者人工耳蜗植入（CI）后听觉和言语康复效果的重要因素，这可能与不同年龄听皮层功能水平有关，听皮层功能评估在CI术前筛查、术后疗效评估，以及神经、精神和心理学相关疾病研究中具有重要意义。听皮层功能评估方法包括神经电生理学、形态学、功能影像学、分子生物学等方面，其中神经电生理学方法操作简单且无创，主要包括基于脑电图（electroencephalography，EEG）的皮层听觉诱发电位（cortical auditory evoked potential，CAEP），如P1-N1-P2波和失匹配负波（mismatch negative，MMN）等，以及基于脑磁图（magnetoencephalography，MEG）的听觉诱发磁场（auditory evoked field，AEF），但AEF检测设备昂贵、操作复杂、环境要求高，应用较少。本文将对听皮层功能的神经电生理学评估方法及其研究进展进行综述。

Abstract

Auditory deprivation time and implantation age are important factors affecting the auditory and speech rehabilitation outcomes of cochlear implantation (CI) in patients with congenital deafness possibly associated with the functional level of the auditory cortex at different developmental stages. In terms of predicting preoperative efficacy

evaluating postoperative efficacy of CI

and conducting research on neurological

psychiatric

and psychological related diseases

the functional evaluation of the auditory cortex is essential. Methods for evaluating auditory cortex function encompass neuroelectrophysiology

morphology

functional imaging

and molecular biology. The neuroelectrophysiological methods have characteristics such as simplicity in operation and non-invasiveness

mainly including cortical auditory evoked potential (CAEP) based on electroencephalography (EEG)

such as P1-N1-P2 waves and mismatch negative (MMN)

and auditory evoked field (AEF) based on magnetoencephalography (MEG). However

AEF is less applied due to its costly detection equipment

complex operation

and stringent environmental requirements. This article will review neuroelectrophysiological evaluation methods and the research progress in auditory cortex function.

关键词

Keywords

references

刘军 . 人工耳蜗植入术前耳蜗神经及后通路功能评估 [J ] . 中国听力语言康复科学杂志 , 2023 , 21 ( 5 ): 449 - 455 .

中华耳鼻咽喉头颈外科杂志编辑委员会 , 中华医学会耳鼻咽喉头颈外科学分会 , 中国残疾人康复协会听力语言康复专业委员会 . 人工耳蜗植入工作指南(2013) [J ] . 中华耳鼻咽喉头颈外科杂志 , 2014 , 49 ( 2 ): 89 - 95 .

Kral A , Dorman MF , Wilson BS . Neuronal development of hearing and language: cochlear implants and critical periods [J ] . Annual review of neuroscience , 2019 , 42 ( 1 ): 47 - 65 .

Helfrich RF , Knight RT . Cognitive neurophysiology: Event-related potentials [J ] . Handbook of clinical neurology , 2019 , 160 : 543 - 558 .

Purdy SC , Kelly AS , Thorne PR . Auditory evoked potentials as measures of plasticity in humans [J ] . Audiology and Neurotology , 2001 , 6 ( 4 ): 211 - 215 .

Lightfoot G . Summary of the N1-P2 cortical auditory evoked potential to estimate the auditory threshold in adults [J ] . Seminars in hearing . Thieme Medical Publishers , 2016 , 37 ( 1 ): 001 - 008 .

Wunderlich JL , Cone-Wesson BK . Maturation of CAEP in infants and children: a review [J ] . Hearing research , 2006 , 212 ( 1-2 ): 212 - 223 .

Jacobson GP . Magnetoencephalographic studies of auditory system function [J ] . Journal of Clinical Neurophysiology , 1994 , 11 ( 3 ): 343 - 364 .

Leite RA , Magliaro FCL , Raimundo JC , et al . Monitoring auditory cortical plasticity in hearing aid users with long latency auditory evoked potentials: a longitudinal study [J ] . Clinics , 2018 , 73 : e51 .

Legris E , Gomot M , Charpentier J , et al . Assessment of auditory discrimination in hearing-impaired patients [J ] . European annals of otorhinolaryngology, head and neck diseases , 2018 , 135 ( 5 ): 335 - 339 .

Feigin L , Tasaka G , Maor I , et al . Sparse coding in temporal association cortex improves complex sound discriminability [J ] . Journal of Neuroscience , 2021 , 41 ( 33 ): 7048 - 7064 .

Van Dun B , Kania A , Dillon H . Cortical auditory evoked potentials in (un) aided normal-hearing and hearing-impaired adults [J ] . Seminars in hearing . Thieme Medical Publishers , 2016 , 37 ( 1 ): 009 - 024 .

Sussman E , Steinschneider M , Gumenyuk V , et al . The maturation of human evoked brain potentials to sounds presented at different stimulus rates [J ] . Hearing research , 2008 , 236 ( 1-2 ): 61 - 79 .

Gürkan S , Başokçu O , Durankaya SM , et al . Central auditory changes associated with age-related hearing loss [J ] . Clinical EEG and Neuroscience , 2024 , 55 ( 4 ): 508 - 517 .

Boo SH , Jeong SW . Cortical auditory evoked potential in adults with Cochlear implants: a comparison with adults with Normal hearing [J ] . Journal of Audiology & Otology , 2022 , 26 ( 1 ): 43 - 49 .

Dabbous AO , Hosni NA , Owais Emara AAS , et al . P1-N1-P2 cortical auditory evoked potentials in chronic unilateral acquired conductive hearing loss in adults [J ] . The Journal of International Advanced Otology , 2024 , 20 ( 3 ): 216 - 224 .

Gommeren H , Bosmans J , Cardon E , et al . Cortical auditory evoked potentials in cognitive impairment and their relevance to hearing loss: a systematic review highlighting the evidence gap [J ] . Frontiers in neuroscience , 2021 , 15 : 781322 .

Sharma A , Campbell J , Cardon G . Developmental and cross-modal plasticity in deafness: evidence from the P1 and N1 event related potentials in cochlear implanted children [J ] . International Journal of Psychophysiology , 2015 , 95 ( 2 ): 135 - 144 .

Vicente LC , Lopes RC , Ventura LM , et al . Development of P1 cortical auditory evoked potential in children presented with sensorineural hearing loss following cochlear implantation: a longitudinal study [C ] . CoDAS . 2013 , 25 ( 6 ): 521 - 526 .

Visram AS , Innes-Brown H , El-Deredy W , et al . Cortical auditory evoked potentials as an objective measure of behavioral thresholds in cochlear implant users [J ] . Hear Res , 2015 , 327 : 35 - 42 .

Näätänen R , Paavilainen P , Rinne T , et al . The mismatch negativity (MMN) in basic research of central auditory processing: a review [J ] . Clinical neurophysiology , 2007 , 118 ( 12 ): 2544 - 2590 .

Näätänen R . Mismatch negativity: clinical research and possible applications [J ] . International Journal of Psychophysiology , 2003 , 48 ( 2 ): 179 - 188 .

李兴启 , 王秋菊 , 冀飞 , 等 . 听觉诱发反应及应用第3版 [M ] . 郑州 : 河南科学技术出版社 , 2024 . 281 - 284 .

朱斌 , 孟子珅 , 胡萍萍 , 等 . 正常听力儿童及青年失匹配负波研究 [J ] . 听力学及言语疾病杂志 , 2021 , 29 ( 1 ): 25 - 28 .

Moore JK , Linthicum Jr FH . The human auditory system: a timeline of development [J ] . International journal of audiology , 2007 , 46 ( 9 ): 460 - 478 .

Ruzzoli M , Pirulli C , Brignani D , et al . Sensory memory during physiological aging indexed by mismatch negativity (MMN) [J ] . Neurobiology of Aging , 2011 , 33 ( 3 ): 625 , e21 - 625 , e30 .

Cooper RJ , Todd J , McGill K , et al . Auditory sensory memory and the aging brain: a mismatch negativity study [J ] . Neurobiology of Aging , 2006 , 27 ( 5 ): 752 - 762 .

Deroche MLD , Wolfe J , Neumann S , et al . Auditory evoked response to an oddball paradigm in children wearing cochlear implants [J ] . Clinical Neurophysiology , 2023 , 149 ( 5 ): 133 - 145 .

Oates PA , Kurtzberg D , Stapells DR . Effects of sensorineural hearing loss on cortical event-related potential and behavioral measures of speech-sound processing [J ] . Ear and hearing , 2002 , 23 ( 5 ): 399 - 415 .

Alzaher M , Strelnikov K , Marx M , et al . Brain plasticity and auditory spatial adaptation in patients with unilateral hearing loss [J ] . Cerebral Cortex , 2023 , 33 ( 11 ): 7221 - 7236 .

Rahne T , Plontke SK , Wagner L . Mismatch negativity (MMN) objectively reflects timbre discrimination thresholds in normal-hearing listeners and cochlear implant users [J ] . Brain research , 2014 , 1586 : 143 - 151 .

Lonka E , Relander-Syrjänen K , Johansson R , et al . The mismatch negativity (MMN) brain response to sound frequency changes in adult cochlear implant recipients: a follow-up study [J ] . Acta oto-laryngologica , 2013 , 133 ( 8 ): 853 - 857 .

Turgeon C , Lazzouni L , Lepore F , et al . An objective auditory measure to assess speech recognition in adult cochlear implant users [J ] . Clinical Neurophysiology , 2014 , 125 ( 4 ): 827 - 835 .

Itoh K , Nejime M , Konoike N , et al . Evolutionary elongation of the time window of integration in auditory cortex: macaque vs. human comparison of the effects of sound duration on auditory evoked potentials [J ] . Frontiers in Neuroscience , 2019 , 13 : 1 - 11 .

Pincze Z , Lakatos P , Rajkai C , et al . Separation of mismatch negativity and the N1 wave in the auditory cortex of the cat: a topographic study [J ] . Clinical Neurophysiology , 2001 , 112 ( 5 ): 778 - 784 .

Tikhonravov D , Neuvonen T , Pertovaara A , et al . Effects of an NMDA-receptor antagonist MK-801 on an MMN-like response recorded in anesthetized rats [J ] . Brain research , 2008 , 1203 : 97 - 102 .

Umbricht D , Vyssotki D , Latanov A , et al . Deviance-related electrophysiological activity in mice: is there mismatch negativity in mice? [J ] . Clinical Neurophysiology , 2005 , 116 ( 2 ): 353 - 363 .

Takahashi H , Nakao M , Kaga K . Multiple neural origins of early auditory evoked potential of rat [J ] . Neuroscience , 2007 , 148 ( 4 ): 845 - 856 .

Shiramatsu TI , Takahashi H . Mismatch-negativity (MMN) in animal models: Homology of human MMN? [J ] . Hearing Research , 2021 , 399 : 107936 .

Guo W , Yang S . Advantages of a miniature pig model in research on human hereditary hearing loss [J ] . Journal of otology , 2015 , 10 ( 3 ): 105 - 107 .

Lunney JK , Van Goor A , Walker KE , et al . Importance of the pig as a human biomedical model [J ] . Science translational medicine , 2021 , 13 ( 621 ): eabd5758 .

Views

127

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Multifactorial Analysis of the Disease Burden in Age-Related Hearing Loss

Analysis of Hearing Aid Effectiveness in Patients with Age-related Hearing Loss

Quality of Life Assessment of Children with Cochlear Implants in Shanghai: A Retrospective Analysis Based on the Nijmegen Scale

Exploration and Practice of a Full-Chain Hearing Health Talent Training Model of Aiding Hearing, Rehabilitation, Research and Development at Career Colleges

Analysis of the Effect of Bilateral Cochlear Implantation and Bimodal Stimulation in Later-implanted Patients with Prelingual Deafness

Related Author

No data

Related Institution

No data

⁰