Recent Development of Gene Therapy for Hereditary Deafness

LING Na-na; GUO Yu-fen; XU Bai-cheng

doi:10.3969/j.issn.1672-4933.2023.04.015

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Recent Development of Gene Therapy for Hereditary Deafness

Review | 更新时间：2026-07-14

- Recent Development of Gene Therapy for Hereditary Deafness
- Chinese Scientific Journal of Hearing and Speech Rehabilitation Vol. 21, Issue 4, Pages: 394-398(2023)
- 作者机构：
  
  1.兰州大学第二医院耳鼻咽喉头颈外科兰州 730000
  2.西安市人民医院（西安市第四医院）耳鼻咽喉头颈外科西安 710000
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1672-4933.2023.04.015
  CLC：
- Received：15 April 2022，
  
  Published：15 July 2023
- 稿件说明：
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令娜娜,郭玉芬,徐百成.遗传性听力障碍的基因治疗研究进展[J].中国听力语言康复科学杂志,2023,21(04):394-398.

LING Na-na,GUO Yu-fen,XU Bai-cheng.Recent Development of Gene Therapy for Hereditary Deafness[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2023,21(04):394-398.
令娜娜,郭玉芬,徐百成.遗传性听力障碍的基因治疗研究进展[J].中国听力语言康复科学杂志,2023,21(04):394-398. DOI： 10.3969/j.issn.1672-4933.2023.04.015.

LING Na-na,GUO Yu-fen,XU Bai-cheng.Recent Development of Gene Therapy for Hereditary Deafness[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2023,21(04):394-398. DOI： 10.3969/j.issn.1672-4933.2023.04.015.

摘要

听力障碍是常见的感觉障碍性疾病之一，目前用于治疗遗传性听力障碍的临床选择有限，主要是通过配戴助听器或植入人工耳蜗等补偿或重建听力，并不能恢复自然听力。从病理学来说，恢复生理听觉是听力障碍治疗的必然目标，因此基因治疗才是听力障碍康复的最终方法。目前遗传性听力障碍的基因治疗还处在动物实验阶段，如何强化该基础研究并促进其向临床转化，是未来研究的重点。本文对遗传性听力障碍基因治疗的现状、发展前景和挑战等进行文献复习和发展展望。

Abstract

Deafness is one of the common sensory disorders. At present

the clinical options for the treatment of hereditary deafness are still very limited

mainly by wearing hearing aids or undergoing cochlear implant surgery to compensate the hearing. In fact

natural hearing cannot be restored. From the pathological point of view

restoring physiological hearing is the inevitable goal of deafness treatment

so in this sense

a gene therapy is the ultimate method of deafness rehabilitation. At present

the gene therapy of hereditary deafness is still in the stage of animal experiments. How to strengthen this basic research and promote its transformation into clinical are the focus of future research. This article reviews the current status

development prospects and challenges of gene therapy for hereditary deafness.

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