Application of Translational Medicine to the Field of Otology

HE Xi-jie; WANG Qian; LI Shi-bo; ZHONG Shi-xun; JI Fei

doi:10.3969/j.issn.1672-4933.2023.03.017

您当前的位置：

首页 >

文章列表页 >

Application of Translational Medicine to the Field of Otology

Review | 更新时间：2023-05-22

- Application of Translational Medicine to the Field of Otology
- Chinese Scientific Journal of Hearing and Speech Rehabilitation Vol. 21, Issue 3, Pages: 290-293(2023)
- 作者机构：
  
  1.解放军总医院耳鼻咽喉头颈外科医学部/国家耳鼻咽喉疾病临床医学研究中心北京 100853
  2.重庆医科大学附属第一医院重庆 400042
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1672-4933.2023.03.017
  CLC：
- Published：15 May 2023，
  
  Received：13 March 2023，
- 稿件说明：
移动端阅览
何玺洁,王倩,李世博等.转化医学在耳科领域中的应用[J].中国听力语言康复科学杂志,2023,21(03):290-293.

HE Xi-jie,WANG Qian,LI Shi-bo,et al.Application of Translational Medicine to the Field of Otology[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2023,21(03):290-293.
何玺洁,王倩,李世博等.转化医学在耳科领域中的应用[J].中国听力语言康复科学杂志,2023,21(03):290-293. DOI： 10.3969/j.issn.1672-4933.2023.03.017.

HE Xi-jie,WANG Qian,LI Shi-bo,et al.Application of Translational Medicine to the Field of Otology[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2023,21(03):290-293. DOI： 10.3969/j.issn.1672-4933.2023.03.017.

摘要

转化医学是生物—心理—社会医学模式下打破传统藩篱的重要概念，主张以患者为中心，强调多学科合作，其核心是将医学生物学基础研究成果转化为临床实践中应用的理论、技术、方法和药物，实现基础研究和临床研究间的双向转化，提高医疗总体水平。听力障碍是人类常见的残疾之一。本文就转化医学在耳科领域中的应用进行文献综述，介绍了人工耳蜗改进、耳聋基因检测与治疗、内耳药物治疗及药物递送技术、成人听力康复技术，总结现有研究成果、不足及未来方向，对于耳科及听觉科学中基础研究与临床应用的相互转化，下一步发展临床可用的各种类型听力损失的干预和康复技术具有重要意义。

Abstract

Translational medicine is an important concept in the bio-psycho-social medicine model that breaks the traditional barriers

advocates patient-centeredness and emphasizes multidisciplinary cooperation. Its core is to translate the results of basic research in medical biology into theories

technologies

methods and drugs that can be applied in clinical practice

to achieve a two-way translation between basic and clinical research

and to improve the overall level of medical treatment. Hearing impairment is one of the most common human disabilities. In this paper

we present a literature review on the application of translational medicine in the field of otology

and introduce cochlear implant improvement

gene therapy for deafness

inner ear drug therapy and delivery techniques

unilateral hearing loss intervention

and hearing rehabilitation techniques for adults. We summarize existing research results

shortcomings

and future directions

which is of great significance to the next development for clinically available intervention and rehabilitation techniques for various types of hearing loss.

关键词

转化医学耳科听觉科学

Keywords

Translational medicineOtologyAuditory science

references

转化医学杂志编辑部.转化医学概念[J].转化医学杂志,2012,1(1):48-48.

谢静,贺璐,龚树生.WHO世界听力报告的解读与思考[J].中华耳鼻咽喉头颈外科杂志,2021,56(10):1131-1135.

Zhang W, Kim SM, Wang W, et al.Cochlear Gene Therapy for Sensorineural Hearing Loss: Current Status and Major Remaining Hurdles for Translational Success[J].Front Mol Neurosci,2018,11:221-221.

Lenz DR, Avraham KB. Hereditary hearing loss: From human mutation to mechanism[J]. Hearing Research, 2011, 281(1-2):3-10.

Yuan Y, You Y, Huang D, et al. Comprehensive molecular etiology analysis of nonsyndromic hearing impairment from typical areas in China[J]. Journal of Translational Medicine, 2009, 7(1): 1-12.

Sacheli R, Delacroix L, Vandenackerveken P, et al. Gene transfer in inner ear cells: a challenging race[J]. Gene Therapy, 2013, 20(3):237-247.

Gao X, Tao Y, Lamas V, et al. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents[J]. Nature, 2018,553(7687):217-221.

蔡洁青,张宏征.人工耳蜗植入者音乐训练及中枢重塑研究进展[J].中华医学杂志,2018,98(26):2134-2136.

吴雨桐,徐百成,郭玉芬.人工耳蜗植入者音乐感知能力的研究进展[J].中华耳科学杂志,2021,19(3):518-521.

Moser T. Optogenetic stimulation of the auditory pathway for research and future prosthetics[J]. Current Opinion in Neurobiology, 2015, 34:29-36.

De Seta, Torres R, Russo F, et al. Damage to inner ear structure during cochlear implantation: Correlation between insertion force and radio-histological findings in temporal bone specimens [J]. Hearing Research, 2017, 344: 90-97.

于浩然,贾欢,杨军. 内耳局部给药抑制人工耳蜗植入后炎症反应和纤维化的研究进展[J]. 中华耳鼻咽喉头颈外科杂志, 2019, 54(1): 69-72.

于浩然,黄玉宇,陈君敏,等.人工耳蜗电极表面载药膜的制备与听力保护作用[J].中华耳科学杂志,2021,19(1):108-112.

Chen W, Jongkamonwiwat N, Abbas L, et al. Restoration of auditory evoked responses by human ES-cell-derived otic progenitors[J]. Nature, 2012,490(7419):278-282.

Glueckert R, Johnson Chacko L, Rask-Andersen H, et al. Anatomical basis of drug delivery to the inner ear[J]. Hearing Research, 2018,368:10-27.

Isherwood B, Gonçalves AC, Cousins R, et al. The global hearing therapeutic pipeline: 2021[J]. Drug Discov Today, 2022,27(3):912-922.

Shi X,Wang Z, Ren W,et al. (2022). LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB)[J]. Signal transduction and targeted therapy, 2022,7(1):2533-2544.

Boothroyd A. Adult Aural Rehabilitation: What Is It and Does It Work?[J].Trends in Hearing, 2007,11(2):63-71.

田宏斌,李佳龄.以人为本的理念及其核心要素在复杂型成人听力管理案例中的应用[J].中国听力语言康复科学杂志.2022,20(6):417-419.

Ferguson M, Maidment D, Henshaw H, et al. Evidence-Based Interventions for Adult Aural Rehabilitation: That Was Then, This Is Now[J]. Seminars in Hearing, 2019, 40(1):68-84.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰