Mechanism and Treatment of Hearing Impairment in Diabetic Patients

LI Hua-ping; XI Kai

doi:10.3969/j.issn.1672-4933.2023.03.014

您当前的位置：

首页 >

文章列表页 >

Mechanism and Treatment of Hearing Impairment in Diabetic Patients

Review | 更新时间：2023-05-22

- Mechanism and Treatment of Hearing Impairment in Diabetic Patients
- Chinese Scientific Journal of Hearing and Speech Rehabilitation Vol. 21, Issue 3, Pages: 277-281(2023)
- 作者机构：
  
  河南科技大学临床医学院/河南科技大学第一附属医院耳鼻喉科洛阳 471003
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1672-4933.2023.03.014
  CLC：
- Published：15 May 2023，
  
  Received：29 June 2022，
- 稿件说明：
移动端阅览
李花萍,席恺.糖尿病患者听力损害的发生机制[J].中国听力语言康复科学杂志,2023,21(03):277-281.

LI Hua-ping,XI Kai.Mechanism and Treatment of Hearing Impairment in Diabetic Patients[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2023,21(03):277-281.
李花萍,席恺.糖尿病患者听力损害的发生机制[J].中国听力语言康复科学杂志,2023,21(03):277-281. DOI： 10.3969/j.issn.1672-4933.2023.03.014.

LI Hua-ping,XI Kai.Mechanism and Treatment of Hearing Impairment in Diabetic Patients[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2023,21(03):277-281. DOI： 10.3969/j.issn.1672-4933.2023.03.014.

摘要

糖尿病是一种临床常见的老年基础性疾病，常合并听力损害。糖尿病患者中约有35%～50%最终发生不同严重程度的听力损伤，主要表现为高频听力下降，双侧对称性、进行性起病，伴有或不伴有眩晕、耳鸣等症状。其发病机制较复杂，高糖引起的血管及神经病变会对糖尿病患者耳蜗代谢、耳蜗微循环及其结构和功能带来变化，但其具体发病基础和机制尚不明确。本文主要对糖尿病患者听力损害的发病机制及其治疗进展进行综述。

Abstract

Diabetes is a common clinical basic disease in the elderly

often accompanied by complications - hearing impairment. Previous studies have shown that about 35%~50% of diabetic patients eventually suffer from different severities of hearing loss. Hearing loss is mainly manifested by high frequency hearing loss

bilateral symmetry

progressive onset

accompanied by or without vertigo

tinnitus and other symptoms. The pathogenesis of this disease is rather complicated. It is believed that the changes of cochlea metabolism and cochlear microcirculation and its structure and function may be caused by high glucose induced vascular and neuropathy. However

the specific pathogenesis and mechanism of this hearing loss are not yet clear. This article mainly reviews the pathogenesis and treatment progress of hearing impairment in diabetic patients.

关键词

糖尿病听力损失发生机制治疗进展

Keywords

Diabetes mellitusHearing lossOccurrence mechanismTreatment progress

references

李林潘. 中西医结合治疗糖尿病研究进展[J]. 临床检验杂志:电子版, 2018, 7(3):558-558.

马颖钰, 曲雁. 糖尿病听力损伤的研究进展[J]. 国际老年医学杂志, 2009, 30(5):228-232.

易虹, 谢杏强. 2型糖尿病患者听力特征性改变的分析研究[J]. 海军医学杂志, 2021, 42(5):609-612.

黄选兆,汪吉宝,孔维佳,等.实用耳鼻咽喉头颈外科学[M].北京:人民卫生出版社,2007.997.

郝瑾, 傅新星, 华琳,等. 糖尿病相关听力下降[J]. 中华全科医师杂志, 2018, 17(6):428-431.

Hussain RT. Otorhinolaryngology frequency of sensory neural hearing loss in type 2 diabetic patients: an experience from a tertiary level hospital in kashmir[J]. Research gate, 2018, 7(4):246-248.

Majeed S, Mumtaz N, Saqulain G. Prevalence of sensorineural hearing loss among patients of diabetes mellitus in Southern Punjab, Pakistan[J]. Journal of Shifa Tameer-e-Millat University, 2019, 1(1):32-36.

许雯雯, 魏之涵, 张红蕾,等. 老年2型糖尿病患者听觉功能影响因素研究[J]. 中国眼耳鼻喉科杂志, 2021,21(03):189-193.

Arunachalam M, Belaldavar BP, Havaldar RR. Effect of Lipid Profile and Serum Creatinine on Hearing Loss in Diabetics[J]. Acta scientific medical sciences,2021, 5(6):20-27.

高海涛, 曲雁, 张勋,等. 白藜芦醇对糖尿病大鼠内耳损伤的保护作用及机制研究[J]. 听力学及言语疾病杂志, 2018, 26(4):409-413.

Kim D, Roy S. Effects of Diabetes on Mitochondrial Morphology and Its Implications in Diabetic Retinopathy[J]. Investigative ophthalmology & visual science, 2020, 61(10):10-19.

盛海斌, 黄治物, 吴皓. 耳蜗突触病变和隐性听力损失[J]. 听力学及言语疾病杂志, 2016, 24(6):614-617.

籍胤玺, 金毅, 金文波. 糖尿病足病患者瘦素水平与血管内皮舒张功能受损的相关性研究[J]. 中国糖尿病杂志, 2018, 26(11):900-904.

贾占伟, 李凤艺, 何强,等. 2型糖尿病小鼠内质网应激对耳蜗毛细胞退行性变的影响[J]. 吉林大学学报:医学版, 2019, 45(1):51-56.

Yang T, Cai C, Peng A, et al. Exosomes derived from cochlear spiral ganglion progenitor cells prevent cochlea damage from ischemia-reperfusion injury via inhibiting the inflammatory process[J]. Cell and Tissue Research, 2021, 386(2):239-247.

Fukushima H, Cureoglu S, Schachern PA, et al. Effects of Type 2 Diabetes Mellitus on Cochlear Structure in Humans[J]. Archives of otolaryngology-head & neck surgery, 2006, 132(9):934-934.

Mujica-Mota MA, Neel P, Issam S. Hearing loss in type 1 diabetes: Are we facing another microvascular disease? A meta-analysis[J]. International Journal of Pediatric Otorhinolaryngology, 2018, 113(2):38-45.

扶玉珍, 姚方辉. 雷公藤甲素对2型糖尿病小鼠耳蜗毛细胞的保护作用[J]. 解剖学杂志, 2021, 44(1):35-39.

Alaguselvi R, Murugan K. Performance analysis of automated lesion detection of diabetic retinopathy using morphological operation[J]. Signal, Image and Video Processing, 2021, 15(4):797-805.

Zhao B, Zhang Q, Liang X, et al. Quercetin reduces inflammation in a rat model of diabetic peripheral neuropathy by regulating the TLR4/MyD88/NF-κB signalling pathway[J]. European journal of pharmacology, 2021, 912(5):e174067.

Chung SS. Contribution of polyol pathway to diabetes-induced oxidative stress[J]. J Am Soc Nephrol, 2003,14(8 Supp 13):233-236.

Alsbirk KE, Seland JH, Assmus J. Diabetic retinopathy and visual impairment in a Norwegian diabetic coast population with a high dietary intake of fish oils. An observational study[J]. Acta Ophthalmologica, 2021,100(2):532-538.

Ren J, Peng Z, Li C, et al. Hearing Loss in Middle-aged Subjects with Type 2 Diabetes Mellitus[J]. Archives of Medical Research, 2009, 40(1):18-23.

Campos EC, Gattegna R, Raimondi MC, et al. Angiogenesis: possible analogies between the eye and the inner ear[J]. Medical Hypotheses, 2012, 78(5):644-645.

沈文清, 孙易, 漆正堂,等. 葡萄糖转运蛋白1与慢性病关联机制的研究进展[J].生命的化学, 2018, 38(4):595-602.

Rdfa B, Pb A, Mb A, et al. Translational implications of the interactions between hormones and age-related hearing loss[J].Hearing Research, 2020, 402(15):108-113.

阎劲松, 袁丹, 李东升. 糖尿病患者的听力受损特点及其影响因素[J]. 内科急危重症杂志, 2016, 22(2):111-112,152.

刘怡陶, 李永新. 线粒体遗传糖尿病伴耳聋的研究进展[J]. 中国听力语言康复科学杂志, 2019, 17(6):445-448.

Barichello T, Generoso JS, Giridharan VV, et al. Receptor for advanced glycation end products mediates meningitis‐triggered amyloid‐β accumulation and cognitive impairment[J].Alzheimer's & Dementia,2020,16(S3):e047199.

Rajamani S, Senniappan S, Radhakrishnan S. Prevalence and factors influencing sensorineural hearing loss among type II diabetes mellitus patients[J].International Journal of Advances in Medicine, 2018,5(3):732-737.

都燕, 任娟, 罗苗苗. 肌醇和维生素B,D对妊娠糖尿病小鼠炎症及脂代谢的影响及机制探讨[J]. 陕西医学杂志, 2022, 51(2):159-163.

Cameron NE, Cotter MA. Reversal of peripheral nerve conduction and perfusion deficits by the free radical scavenger, BM15.0639, in diabetic rats[J]. Naunyn Schmiedebergs Arch Pharmacol, 1995,352(6):685-690.

Zhou Q, Meng G, Teng F, et al. Effects of astragalus polysaccharide on apoptosis of myocardial microvascular endothelial cells in rats undergoing hypoxia/reoxygenation by mediation of the PI3K/Akt/eNOS signaling pathway [J]. J Cell Biochem, 2018,119(1):806-816.

Lee HC,Kim SJ,Kim KS,et al .Remission in models of lype 1 diabetes by gene therapy using a single—chain insulin analogue[J].Nature,2000,408(6811):483-488.

孙晋,牟宏宇,沈志豪,等.听力损失老年人佩戴助听器前后皮层听觉诱发电位与言语感知的研究[J].听力学及言语疾病杂志,2022,30(1):11-16.

Kelly AS, Purdy SC, Thorne PR. Electrophysiological and speech perception measures of auditory processing in experienced adult cochlear implant users[J]. Clin Neurophysiol, 2005,116(6):1235-1246.

黎梅,谢慧.谢慧教授针药合用治疗糖尿病性耳聋临床经验[J].四川中医, 2019,37(10):13-15.

袁海建,林淑媛,张光际,等.补阴中药治疗糖尿病及其并发症物质基础及机制研究新思路[J].中国中药杂志, 2020,45(3):531-538.

Kahraman M, Ertekin YH, Satman L. The Effects of Kefir on Kidney Tissues and Functions in Diabetic Rats[J]. Probiotics and Antimicrobial Proteins, 2021, 13(166):375-382.

王茗茗,单立影,徐景利. 针灸疗法用于神经性耳鸣患者的疗效及对微循环的影响[J]. 河北医药,2022,44(11):1702-1705.

李静, 张晓哲, 郭会敏,等. 针刺捻转补泻手法为主治疗2型糖尿病合并耳鸣耳聋疗效观察[J].国际中医中药杂志,2016, 38(8):713-716.

许金全,于春华,张珺祎,等.甲钴胺联合银杏叶注射液治疗2型糖尿病耳聋耳鸣的临床效果观察[J].健康大视野,2020,2020(16):88-89.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The Characteristics of Hearing Loss Identified in Children Speech Clinics

The Impact of An Immediate Experience of Hearing Aids on The Self-Esteem Evaluation and Hearing Aids Judgement in The Elderly with Hearing Loss

The Correlation between Tone Burst Auditory Brainstem Response and IT-MAIS Score in Infants with Hearing Loss

Advance in the Treatment of Vocal Nodules in School-Age Children

Research and Application of Tele-Audiometry

Related Author

LIANG Ai-min

CUI Zhi-jun

YIN Meng-ya

SHI Yang

JIN Meng-ke

JIA Xin-yue

QU Chun-yan

TENG Bai-yu

Related Institution

首都医科大学附属北京儿童医院保健中心

大连医科大学附属第一医院耳鼻咽喉科

中国听力语言康复研究中心

复旦大学附属华东医院老年医学临床重点实验室

河北省儿童医院耳鼻咽喉科

⁰