A Case Study of Integrated Medical-Educational Intervention Combined with Low-Intensity Focused Ultrasound in a Child with Autism Spectrum Disorder

CHEN Wei-min; ZHAO Yan-pin; GE Jia-le; TU Shun-shun; ZHU Guo-li; YAN Chao-shan

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A Case Study of Integrated Medical-Educational Intervention Combined with Low-Intensity Focused Ultrasound in a Child with Autism Spectrum Disorder

更新时间：2026-10-19

- A Case Study of Integrated Medical-Educational Intervention Combined with Low-Intensity Focused Ultrasound in a Child with Autism Spectrum Disorder
- Chinese Scientific Journal of Hearing and Speech Rehabilitation Pages: 1-8(2026)
- 作者机构：
  
  同济大学附属养志康复医院上海 201619
- 作者简介：
- 基金信息：
- DOI：
  CLC： G762
- Received：09 May 2025，
  
  Revised：2026-02-17，
  
  Accepted：12 March 2026，
  
  Online First：17 October 2026，
- 稿件说明：
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陈伟民,赵艳嫔,葛佳乐等.医教融合联合低强度聚焦超声干预孤独症谱系障碍儿童个案分析[J].中国听力语言康复科学杂志,

CHEN Wei-min,ZHAO Yan-pin,GE Jia-le,et al.A Case Study of Integrated Medical-Educational Intervention Combined with Low-Intensity Focused Ultrasound in a Child with Autism Spectrum Disorder[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,
陈伟民,赵艳嫔,葛佳乐等.医教融合联合低强度聚焦超声干预孤独症谱系障碍儿童个案分析[J].中国听力语言康复科学杂志, DOI：10.3969/j.issn.1672-4933...001.

CHEN Wei-min,ZHAO Yan-pin,GE Jia-le,et al.A Case Study of Integrated Medical-Educational Intervention Combined with Low-Intensity Focused Ultrasound in a Child with Autism Spectrum Disorder[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation, DOI：10.3969/j.issn.1672-4933...001.

摘要

目的

报告1例学龄前轻度孤独症谱系障碍（ASD）儿童接受医教融合课程联合低强度聚焦超声（low-intensity focused ultrasound，LIFUS）干预及其行为、脑功能连接和社会适应变化。

方法

采用无平行对照的探索性单例前后测设计，对1例4岁9个月男童在持续医教融合训练基础上，加用4周左侧背外侧前额叶LIFUS干预共20次，同期开展12次医教融合课程。干预前、LIFUS结束时及结束后12周，结合行为量表、静息态功能性近红外光谱成像与生态观察进行描述性评估。

结果

与干预前相比，孤独症行为量表和孤独症治疗评估量表总分在干预结束时下降，随访时进一步下降。社交反应量表第二版T分及重复行为量表修订版总分在干预结束时下降，随访时均回升，前者接近基线，后者仍低于基线。双侧前额叶之间及左侧前额叶与双侧感觉运动区之间的功能连接指标在干预结束时升高，随访时仍高于基线。自编幼儿园适应行为量表评分升高，课堂参与增加。患儿完成全部LIFUS疗程，初期出现短暂抗拒和焦虑，未发生导致干预中断的不良事件。

结论

本例为联合干预的实施可行性提供了初步资料。患儿部分行为及适应指标呈改善趋势，伴脑功能连接变化，但随访期不同指标的变化不一。LIFUS的附加作用及联合干预的有效性与安全性仍需进一步验证。

Abstract

Objective

To report the implementation of an integrated medical-educational program combined with low-intensity focused ultrasound (LIFUS) in a preschool child with mild autism spectrum disorder (ASD)

and to describe changes in behavior

functional brain connectivity

and social adaptation.

Methods

An exploratory single-case pre-post design without a parallel control group was used. A boy aged 4 years and 9 months received 20 sessions of LIFUS targeting the left dorsolateral prefrontal cortex over 4 weeks as an adjunct to ongoing integrated medical-educational training

with 12 program sessions delivered during the same period. Descriptive assessments were conducted at baseline

immediately after completion of LIFUS

and at the 12-week follow-up using behavioral rating scales

resting-state functional near-infrared spectroscopy

and naturalistic observations.

Results

Autism Behavior Checklist and Autism Treatment Evaluation Checklist total scores decreased at intervention completion and further at follow-up. The Social Responsiveness Scale

Second Edition total T-score and Repetitive Behavior Scale- Revised total score decreased initially

then increased at follow-up; the former approached baseline

while the latter remained below baseline. Connectivity between bilateral prefrontal regions and between the left prefrontal and bilateral sensorimotor regions increased at intervention completion and remained above baseline at follow-up. Scores on the study-developed Kindergarten Adaptive Behavior Scale increased

as did classroom participation. The child completed all LIFUS sessions

with brief initial resistance and anxiety but no adverse events leading to intervention discontinuation.

Conclusion

Conclusion This case provides preliminary evidence on the feasibility of implementing the combined intervention. Some behavioral and adaptive measures showed favorable trends alongside changes in functional brain connectivity

but follow-up trajectories varied across measures. The added benefit of LIFUS and the efficacy and safety of the combined intervention require further evaluation.

关键词

Keywords

references

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