Correlation Between Vascular Endothelial Factor Levels and Inner Ear Microcirculation and Hearing Loss in Elderly Patients with Sudden Sensorineural Hearing Loss

LIU Tu-hui; LIU Si-yuan; HUANG Xiao-xing; XU Xia

doi:null

您当前的位置：

首页 >

文章列表页 >

Correlation Between Vascular Endothelial Factor Levels and Inner Ear Microcirculation and Hearing Loss in Elderly Patients with Sudden Sensorineural Hearing Loss

更新时间：2026-07-12

- Correlation Between Vascular Endothelial Factor Levels and Inner Ear Microcirculation and Hearing Loss in Elderly Patients with Sudden Sensorineural Hearing Loss
- Chinese Scientific Journal of Hearing and Speech Rehabilitation Pages: 1-6(2026)
- 作者机构：
  
  1.广州市增城区中心医院耳鼻喉科广州 511340
  2.南方医院增城院区耳鼻咽喉科广州 510515
  3.南方医科大学南方医院耳鼻喉头颈外科广州 510000
- 作者简介：
- 基金信息：
- DOI：
  CLC： R764.43+7
- Received：10 April 2025，
  
  Online First：22 June 2026，
- 稿件说明：
移动端阅览
刘土辉,刘思源,黄晓星等.老年突发性耳聋患者血管内皮因子水平与内耳微循环及听力损失的相关性[J].中国听力语言康复科学杂志,

LIU Tu-hui,LIU Si-yuan,HUANG Xiao-xing,et al.Correlation Between Vascular Endothelial Factor Levels and Inner Ear Microcirculation and Hearing Loss in Elderly Patients with Sudden Sensorineural Hearing Loss[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,
刘土辉,刘思源,黄晓星等.老年突发性耳聋患者血管内皮因子水平与内耳微循环及听力损失的相关性[J].中国听力语言康复科学杂志, DOI：10.3969/j.issn.1672-4933...001.

LIU Tu-hui,LIU Si-yuan,HUANG Xiao-xing,et al.Correlation Between Vascular Endothelial Factor Levels and Inner Ear Microcirculation and Hearing Loss in Elderly Patients with Sudden Sensorineural Hearing Loss[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation, DOI：10.3969/j.issn.1672-4933...001.

摘要

目的

探讨老年突发性耳聋患者血管内皮因子水平与内耳微循环及听力损失的相关性。

方法

以2021年3月至2024年6月就诊于我院的老年突发性耳聋患者95例作为研究对象，根据患者听力损失严重程度划分为中度以下听力损失组（n=49）和重度以上听力损失组（n=46）。对比两组患者一般临床资料及疾病特征，测定并对比患者治疗前血管内皮因子［血管内皮生长因子（vascular endothelial growth factor，VEGF）、缺氧诱导因子（hypoxia-inducible factor，HIF）1α、同型半胱氨酸（Hcy）］及内耳微循环指标［可溶性血管细胞黏附分子（soluble vascular cell adhesion molecule，sVCAM）、内皮素（endothelin，ET）］的表达水平差异。通过Spearman相关性检验、单因素及多因素Logistic回归分析评价老年突发性耳聋患者临床特征、血管内皮因子水平与内耳微循环指标与严重听力损失的相关性。

结果

重度以上听力损失组患者平均年龄更高，合并糖尿病（47.8% vs 26.5%，P=0.032）及眩晕的比例显著更高。重度以上听力损失组血清 VEGF、HIF-1α、Hcy、sVCAM及 ET水平均显著高于中度以下听力损失组（

0.001）。Spearman相关性分析显示，上述5项指标均与听力损失严重程度呈正相关（rs=0.431～0.479，

0.001）。多因素 Logistic 回归分析校正年龄、糖尿病等混杂因素后，VEGF（OR=1.342，95% CI：1.064~1.693，

=0.013）、HIF-1α（OR=4.808，95% CI：1.149~6.700，

=0.003）、Hcy（OR=1.546，95% CI：1.021~2.339，

=0.039）、sVCAM（OR=1.097，95% CI：1.0

39~1.158，

0.001）及 ET（OR=1.413，95% CI：1.080~1.849，

=0.012）仍是重度听力损失的独立危险因素。

结论

老年突发性耳聋患者血管内皮损伤及内耳微循环障碍程度与听力损失严重程度密切相关。治疗前检测血清 VEGF、HIF-1α、Hcy、sVCAM及ET水平，可辅助评估病情严重程度，为制订个体化治疗方案提供客观依据。

Abstract

Objective

To explore the relationship between the levels of vascular endothelial factors and the microcirculation of the inner ear in elderly patients with sudden sensorineural hearing loss

as well as its impact on their auditory function.

Methods

95 elderly patients with sudden sensorineural hearing loss were studied at our hospital from March 2021 to June 2024. They were categorized based on the severity of their condition into a mild-to-moderate hearing loss group (n=49) and a severe-to-profound hearing loss group (n=46). A comparison was made between the general clinical profiles and disease characteristics of the two groups. The levels of vascular endothelial factors [vascular endothelial growth factor (VEGF)

hypoxia-inducible factor (HIF) 1α

homocysteine (Hcy)] and inner ear microcirculation indicators [soluble vascular cell adhesion molecule (sVCAM)

endothelin (ET)] were assessed and compared before treatment. The relationship between clinical features

vascular endothelial factor levels

inner ear microcirculation indicators

and the development of severe hearing loss in elderly patients with sudden sensorineural hearing loss was analyzed using Spearman correlation test

as well as univariate and multivariate logistic regression analysis.

Results

Patients in the severe-to-profound hearing loss group had a higher average age

and significantly higher proportions of diabetes mellitus and vertigo. Serum levels of VEGF

HIF-1α

Hcy

sVCAM

and ET in the severe-to-profound hearing loss group were significantly higher than those in the mild-to-moderate hearing loss group (

0.001).

Spearman correlation analysis showed that all five indicators were positively correlated with the severity of hearing loss (rs=0.431-0.479

0.001).After adjusting for confounding factors such as age and diabetes mellitus

multivariate logistic regression analysis showed that VEGF(OR=1.342

95%CI:1.064-1.693

=0.013)

HIF-1α(OR=4.808

95%CI:1.149-6.700

=0.003)

Hcy(OR=1.546

95%CI:1.021-2.339

=0.039)

sVCA(OR=1.097

95%CI:1.039-1.158

0.001)

and ET(OR=1.413

95%CI:1.080-1.849

=0.012) remained independent risk factors for severe hearing loss.

Conclusion

The degree of vascular endothelial injury and inner ear microcirculation disturbance is closely related to the severity of hearing loss in elderly patients with SSNHL. Detection of serum VEGF

HIF-1α

Hcy

sVCAM

and ET levels before treatment can assist in assessing the severity of the disease and provide an objective basis for formulating individualized treatment plans.

关键词

Keywords

references

Tripathi P , Deshmukh P . Sudden Sensorineural Hearing Loss: A Review [J ] . Cureus , 2022 , 14 ( 9 ): e29458 .

Xie W , Karpeta N , Tong B , et al . Etiological analysis of patients with sudden sensorineural hearing loss: a prospective case-control study [J ] . Sci Rep , 2023 , 13 ( 1 ): 5221 .

付剑芬 , 傅江涛 , 林洪斌 , 等 . 老年突发性耳聋流行病学特征及发病相关影响因素和预防措施分析 [J ] . 中国预防医学杂志 , 2019 , 20 ( 11 ): 1036 - 1039 .

贾岩峰 , 杨相立 . 特发性突聋糖皮质激素治疗的研究进展 [J ] . 山东医药 , 2023 , 63 ( 16 ): 108 - 111 .

胡潇红 , 宁荣霞 . 突发性耳聋的发病机制与治疗康复现状 [J ] . 中国康复 , 2020 , 35 ( 9 ): 496 - 500 .

陶杰 , 白忠 . 内耳微循环障碍危险因素与突发性耳聋的研究进展 [J ] . 世界最新医学信息文摘(连续型电子期刊) , 2024 , 24 ( 20 ): 17 - 21,27 .

肖琪 , 张丹慧 , 刘蓬 , 等 . 中医综合治疗难治性突聋的临床疗效观察 [J ] . 广州中医药大学学报 , 2024 , 41 ( 6 ): 1486 - 1492 .

中华耳鼻咽喉头颈外科杂志编辑委员会 , 中华医学会耳鼻咽喉头颈外科学分会 . 突发性聋诊断和治疗指南(2015) [J ] . 中华耳鼻咽喉头颈外科杂志 , 2015 , 50 ( 6 ): 443 - 447 .

Chandrasekhar SS , Tsai Do BS , Schwartz SR , et al . Clinical practice guideline: sudden hearing loss (update) [J ] . Otolaryngol Head Neck Surg , 2019 , 161 ( 1_suppl ): S1 - S45 .

Xie W , Karpeta N , Tong B , et al . Comorbidities and laboratory changes of sudden sensorineural hearing loss: a review [J ] . Front Neurol , 2023 , 14 : 1142459 .

Plontke SK . Diagnostics and therapy of sudden hearing loss [J ] . GMS Curr Top Otorhinolaryngol Head Neck Surg , 2018 , 16 : Doc05 .

王晓燕 , 李化静 . 老年突发性耳聋患者血管内皮因子水平与内耳微循环及听力损伤的相关性 [J ] . 临床医学研究与实践 , 2025 , 10 ( 20 ): 99 - 102 .

Gallo G , Volpe M , Savoia C . Endothelial Dysfunction in hypertension: current concepts and clinical implications [J ] . Front Med (Lausanne) , 2022 , 8 : 798958 .

Qiu B , Yuan P , Du X , et al . Hypoxia inducible factor-1α is an important regulator of macrophage biology [J ] . Heliyon , 2023 , 9 ( 6 ): e17167 .

She W , Gao Z , Zhu W , et al . Up-regulation of HIF-1α in refractory sudden sensorineural hearing loss [J ] . Acta Otorhinolaryngol Ital , 2024 , 44 ( 5 ): 333 - 341 .

Picciotti PM , Torsello A , Cantore I , et al . Expression of vascular endothelial growth factor and its receptors in the cochlea of various experimental animals [J ] . Acta Otolaryngol , 2005 , 125 ( 11 ): 1152 - 1157 .

杨家月 , 杨莉 , 刘勇 . 银杏叶提取物联合复方倍他米松耳后注射治疗突发性耳聋的临床效果 [J ] . 保健医学研究与实践 , 2024 , 21 ( 3 ): 49 - 54 .

刘美畅 , 王金渊 , 薛茜 , 等 . 突发性耳聋听力损失患者血脂代谢、血液流变学指标、血清缺氧诱导因子-1α和血管内皮生长因子水平变化 [J ] . 微循环学杂志 , 2025 , 35 ( 1 ): 21 - 25,31 .

Papatheodorou L , Weiss N . Vascular oxidant stress and inflammation in hyperhomocysteinemia [J ] . Antioxid Redox Signal , 2007 , 9 ( 11 ): 1941 - 1958 .

蔡章达 , 高金虎 . 基于血脂、血浆纤维蛋白原、Hcy等参数构建突发性耳聋发病预测模型相关研究 [J ] . 医学理论与实践 , 2024 , 37 ( 11 ): 1826 - 1829 .

吴琼芳 , 梁佳 , 马喆 , 等 . 血清可溶性血管细胞黏附分子-1、同型半胱氨酸以及D-二聚体水平与突发性耳聋患者内耳微循环障碍的关系 [J ] . 实用临床医药杂志 , 2025 , 29 ( 12 ): 62 - 66 .

Niu X , Chen Y , Zhong Y , et al . The relationship between serum homocysteine levels and sudden sensorineural hearing loss: a meta-analysis [J ] . Eur Arch Otorhinolaryngol , 2023 , 280 ( 5 ): 2091 - 2097 .

Huang Y , Lv T , Xie M , et al . Blood homocysteine and folic acid levels may provide reference value for the treatment of sudden total frequency deafness [J ] . Ann Palliat Med , 2019 , 8 ( 5 ): 604 - 610 .

Corazzi V , Migliorelli A , Bianchini C , et al . Hearing Loss and Blood Coagulation Disorders: A Review [J ] . Hematol Rep , 2023 , 15 ( 3 ): 421 - 431 .

Cowen JE , Tehrani MS , Connor SEJ . The Association of Vascular Loops within the Internal Auditory Meatus or Contacting the Vestibulo-Cochlear Nerve with Audiovestibular Symptoms: A Systematic Review and Meta-Analysis [J ] . AJNR Am J Neuroradiol , 2025 , 46 ( 2 ): 372 - 379 .

Lawrence M . Control mechanisms of inner ear microcirculation [J ] . Am J Otolaryngol , 1980 , 1 ( 4 ): 324 - 333 .

Cavallaro G , Pantaleo A , Pontillo V , et al . Endothelial dysfunction and metabolic disorders in patients with sudden sensorineural hearing loss [J ] . Medicina (Kaunas) , 2023 , 59 ( 10 ): 1718 .

Noskova VV , Khrabrikov AN . Correlation between endothelial dysfunction and sensorineural hearing loss [J ] . Vestn Otorinolaringol , 2025 , 90 ( 3 ): 13 - 18 .

谢书华 , 杨竹梅 , 刘慧茹 , 等 . 血浆ET-1、D-D、sVCAM-1、ICAM-1水平预测突发性耳聋患者预后的价值 [J ] . 徐州医科大学学报 , 2024 , 44 ( 1 ): 32 - 36 .

Wang ZH , Zhang HL . Relationship Between serum ET-1,HDL-C,and sVCAM-1 and hearing loss in patients with sudden deafness [J ] . Appl Biochem Biotechnol , 2024 , 196 ( 3 ): 1376 - 1385 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical Features, Prognostic Factors and Prediction Model in Sudden Sensorineural Hearing Loss with Vertigo

The Psychosocial Impact Factors of Sudden Sensorineural Hearing Loss in Middle-aged and Young Adults: in Sleep Quality, Emotional State, and Hearing Impairment

Analysis of Hearing Loss and Influencing Factors in 288 Children with Otitis Media with Effusion

Design and Implementation of a Portable Rapid Speech Audiometry System

The Current Situation and Influencing Factors of Hearing Loss in Children with Autism Spectrum Disorder

Related Author

LI Juan-juan

CHEN Xi

GUAN Gui-hao

MA Fang

WEI Jian-fang

ZHANG Yan-hong

WANG Zhao-Xia

LIN Yu-lian

Related Institution

深圳市龙岗区耳鼻咽喉医院

成都市中西医结合医院耳鼻喉科

厦门大学附属成功医院暨陆军第73集团军医院

滨州医学院特殊教育与康复学院

解放军总医院第六医学中心耳鼻咽喉头颈外科医学部研究所

⁰