皮层听觉诱发电位在儿童人工耳蜗植入评估中的应用
The Application of Cortical Auditory Evoked Potential to the Evaluation of Cochlear Implantation in Children
- 中国听力语言康复科学杂志 2026年24卷第1期 页码：20-24
- 作者机构：
中国医科大学附属第一医院耳鼻咽喉科 沈阳 110001
- 作者简介：
田颖 博士 副主任医师；研究方向：耳科学
王菲， E-mail： feiwang@cmu.edu.cn
- 基金信息：辽宁省教育厅基本科研项目“耳蜗巨噬细胞调控谷氨酸代谢在听力损伤中影响带状突触可塑性的作用及机制研究”(LJKMZ20221144)
DOI：10.3969/j.issn.1672-4933.2026.01.004
中图分类号： R764.35收稿：2025-08-30，
纸质出版：2026-01-15
- 稿件说明：
移动端阅览
田颖,罗扬拓,王菲.皮层听觉诱发电位在儿童人工耳蜗植入评估中的应用[J].中国听力语言康复科学杂志,2026,24(01):20-24.
TIAN Ying,LUO Yang-tuo,WANG Fei.The Application of Cortical Auditory Evoked Potential to the Evaluation of Cochlear Implantation in Children[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2026,24(01):20-24.
田颖,罗扬拓,王菲.皮层听觉诱发电位在儿童人工耳蜗植入评估中的应用[J].中国听力语言康复科学杂志,2026,24(01):20-24. DOI： 10.3969/j.issn.1672-4933.2026.01.004.
TIAN Ying,LUO Yang-tuo,WANG Fei.The Application of Cortical Auditory Evoked Potential to the Evaluation of Cochlear Implantation in Children[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2026,24(01):20-24. DOI： 10.3969/j.issn.1672-4933.2026.01.004.
摘要
皮层听觉诱发电位（cortical auditory evoked potentials， CAEP）是大脑皮层接收声音刺激后产生的生物电反应，为客观评估听觉通路的功能，特别是中枢听觉处理能力，提供重要窗口。CAEP动态监测技术通过量化P1、N1、P2等核心参数，为人工耳蜗植入（CI）儿童术后的神经重塑与精准康复提供了关键评估手段。人工耳蜗植入后大脑听觉皮层的电生理变化标志着听觉功能的成熟与重组，双侧CI使用者呈现半球优势转移现象，揭示大脑跨模态重组机制，结合认知训练可显著提升特殊需要人群的言语识别率。然而，当前领域面临标准化体系缺失与个体差异干扰等瓶颈，未来需构建多中心数据库并融合神经影像技术，建立神经响应-行为表现-中枢机制多模态评估模式，推动康复策略向神经适配跃迁，全面赋能重度感音神经性聋人工耳蜗植入儿童的神经可塑性潜能。
Abstract
CAEP is a bio-electric response generated by the cerebral cortex after receiving sound stimulation
providing an important window for us to objectively assess the function of the auditory pathway
especially the central auditory processing ability. The dynamic monitoring technology of CAEP quantifies core parameters such as P1
N1
and P2
offering a key assessment method for neural remodeling and precise rehabilitation after cochlear implantation (CI) in children. Research shows that the electrophysiological changes in the auditory cortex of the brain after cochlear implantation mark the maturation and reorganization of auditory function. Bilateral CI recipients exhibit a phenomenon of hemispheric dominance transfer
revealing the brain's cross-modal reorganization mechanism. Combined with cognitive training
it can significantly improve the speech recognition rate of special populations. However
the current field faces bottlenecks such as the lack of a standardized system and the interference of individual differences. In the future
it is necessary to build a multi-center database and integrate functional neuroimaging technology to establish a multi-modal assessment model of "neural response-behavioral performance-central mechanism"
promoting the leap of rehabilitation strategies to "neural adaptation" and fully empowering the neural plasticity potential of children with severe sensorineural hearing loss who have undergone cochlear implantation.
关键词
Keywords
references
Xiong S , Jiang L , Wang Y , et al . The Role of the P1 Latency in Auditory and Speech Performance Evaluation in Cochlear Implanted Children [J ] . Neural Plast , 2022 , 2022 : 6894794 .
Cone B , Whitaker R . Dynamics of infant cortical auditory evoked potentials (CAEPs) for tone and speech tokens [J ] . Int J Pediatr Otorhinolaryngol , 2013 , 77 ( 7 ): 1162 - 1173 .
Franlund K , Lindehammar H , Maki-Torkko E , et al . Cortical auditory evoked potentials (P1 latency) in children with cochlear implants in relation to clinical language tests [J ] . Int J Audiol , 2024 , 63 ( 10 ): 802 - 808 .
Chang HW , Dillon H , Carter L , et al . The relationship between cortical auditory evoked potential (CAEP) detection and estimated audibility in infants with sensorineural hearing loss [J ] . Int J Audiol , 2012 , 51 ( 9 ): 663 - 670 .
Small SA , Ishida IM , Stapells DR . Infant Cortical Auditory Evoked Potentials to Lateralized Noise Shifts Produced by Changes in Interaural Time Difference [J ] . Ear Hear , 2017 , 38 ( 1 ): 94 - 102 .
Shehata-Dieler W , Grossmann W . Preoperative auditory evaluation and postoperative follow-up in cochlear implantees : The role of objective measures [J ] . HNO , 2017 , 65 ( 4 ): 298 - 307 .
Abdi-Sargezeh B , Foodeh R , Shalchyan V , et al . EEG artifact rejection by extracting spatial and spatio-spectral common components [J ] . J Neurosci Methods , 2021 , 358 : 109182 .
Polterauer D , Neuling M , Simon F . Tympanic Pre-Operative Electrically Evoked Auditory Late Response (TympEALR) as an Alternative to Trans-Tympanic Tests Using Anesthesia in Cochlear Implant Candidacy [J ] . J Clin Med , 2024 , 13 ( 24 ): 7573 .
Alouit A , Gavaret M , Ramdani C , et al . Cortical activations induced by electrical versus vibrotactile finger stimulation using EEG [J ] . Neuroimage , 2025 , 314 : 121249 .
Tomlin D , Rance G . Maturation of the Central Auditory Nervous System in Children with Auditory Processing Disorder [J ] . Semin Hear , 2016 , 37 ( 1 ): 74 - 83 .
Pantelemon C , Necula V , Livint PL , et al . The Potential Use of P1 CAEP as a Biomarker for Assessing Central Auditory Pathway Maturation in Hearing loss and Associated Disabilities: a case report [J ] . J Med Life , 2019 , 12 ( 4 ): 457 - 460 .
Saki N , Nikakhlagh S , Moridi B , et al . Cortical Auditory Plasticity Following Cochlear Implantation in Children With Auditory Neuropathy Spectrum Disorder: A Prospective Study [J ] . Otol Neurotol , 2021 , 42 ( 9 ): e1227 - e1233 .
Purcell PL , Deep NL , Waltzman SB , et al . Cochlear Implantation in Infants: Why and How [J ] . Trends Hear , 2021 , 25 : 1851345095 .
McKinney S . Cochlear implantation in children under 12 months of age [J ] . Curr Opin Otolaryngol Head Neck Surg , 2017 , 25 ( 5 ): 400 - 404 .
Roque L , Karawani H , Gordon-Salant S , et al . Effects of Age, Cognition, and Neural Encoding on the Perception of Temporal Speech Cues [J ] . Front Neurosci , 2019 , 13 : 749 .
Deniz H . Auditory Performance and Cortical Plasticity Following Late Sequential Cochlear Implantation [J ] . Audiol Neurootol , 2025 , 30 ( 6 ): 526 - 534 .
Anderson S , White-Schwoch T , Parbery-Clark A , et al . Reversal of age-related neural timing delays with training [J ] . Proc Natl Acad Sci U S A , 2013 , 110 ( 11 ): 4357 - 4362 .
Sharma A , Glick H , Campbell J , et al . Cortical Plasticity and Reorganization in Pediatric Single-sided Deafness Pre-and Postcochlear Implantation: A Case Study [J ] . Otol Neurotol , 2016 , 37 ( 2 ): e26 - e34 .
Sharma A , Cormier K , Grigsby J . Effect of Supplemental Language Therapy on Cortical Neuroplasticity and Language Outcomes in Children with Hearing Loss [J ] . Brain Sci , 2025 , 15 ( 2 ): 119 .
Attias J , HabibAllah S , Aditya TV , et al . Cortical Auditory Evoked Potentials Recorded Directly Through the Cochlear Implant in Cochlear Implant Recipients: a Feasibility Study [J ] . Ear Hear , 2022 , 43 ( 5 ): 1426 - 1436 .
Morlet T , Valania J , Walter C , et al . Cortical Auditory Evoked Potential Testing in Children With Auditory Neuropathy Spectrum Disorder [J ] . Am J Audiol , 2023 , 4 : 1 - 12 .
Buell EP , Borland MS , Loerwald KW , et al . Vagus Nerve Stimulation Rate and Duration Determine whether Sensory Pairing Produces Neural Plasticity [J ] . Neuroscience , 2019 , 406 : 290 - 299 .
Thabet MT , Said NM . Cortical auditory evoked potential (P1): a potential objective indicator for auditory rehabilitation outcome [J ] . Int J Pediatr Otorhinolaryngol , 2012 , 76 ( 12 ): 1712 - 1718 .
Ibraheem OA , Abdelghani M , Hassan EM , et al . Multidisciplinary Cognitive Function Assessment of Good versus Poor Performance in Children with Cochlear Implants: An Observational Cross-Sectional Study [J ] . Int Arch Otorhinolaryngol , 2023 , 27 ( 3 ): e445 - e454 .
Horton RH , Mcintosh A , Ostinelli EG , et al . Neuropsychiatric Outcomes in Children and Adolescents With Perinatally Acquired HIV: A Systematic Review and Meta-Analysis [J ] . J Acquir Immune Defic Syndr , 2025 , 98 ( 5 ): 411 - 428 .
Roze E , Reijneveld SA , Stewart RE , et al . Multi-domain cognitive impairments at school age in very preterm-born children compared to term-born peers [J ] . BMC Pediatr , 2021 , 21 ( 1 ): 169 .
Zhang F , McGuire K , Firestone G , et al . Cortical processing of location and frequency changes of sounds in normal hearing listeners [J ] . Hear Res , 2021 , 400 : 108110 .
Datta D , Conroy AL , Castelluccio PF , et al . Elevated Cerebrospinal Fluid Tau Protein Concentrations on Admission Are Associated With Long-term Neurologic and Cognitive Impairment in Ugandan Children With Cerebral Malaria [J ] . Clin Infect Dis , 2020 , 70 ( 6 ): 1161 - 1168 .
Sharma A , Cardon G . Cortical development and neuroplasticity in Auditory Neuropathy Spectrum Disorder [J ] . Hear Res , 2015 , 330 ( Pt B ): 221 - 232 .
Ma EZ , Chang HR , Radtke S , et al . Symptoms of Cognitive Impairment Among Children With Atopic Dermatitis [J ] . JAMA Dermatol , 2024 , 160 ( 4 ): 447 - 452 .
Leaver AM , Chen YJ , Parrish TB . Focal transcranial direct current stimulation of auditory cortex in chronic tinnitus: A randomized controlled mechanistic trial [J ] . medRxiv , 2023 , 158 : 79 - 91 .
Sorg AL , Von Kries R , Borggraefe I . Cognitive disorders in childhood epilepsy: a comparative longitudinal study using administrative healthcare data [J ] . J Neurol , 2022 , 269 ( 7 ): 3789 - 3799 .
Uher I , Pivovarnik J , Majherova M . Sensory Modality in Students Enrolled in a Specialized Training Program for Security Forces and Its Impact on Karate Performance Indicators [J ] . J Funct Morphol Kinesiol , 2025 , 10 ( 2 ): 114 .
Leisman G , Wallach J , Machado-Ferrer Y , et al . Binaural Pulse Modulation (BPM) as an Adjunctive Treatment for Anxiety: A Pilot Study [J ] . Brain Sci , 2025 , 15 ( 2 ): 147 .
Mushtaq F , Wiggins IM , Kitterick PT , et al . The Benefit of Cross-Modal Reorganization on Speech Perception in Pediatric Cochlear Implant Recipients Revealed Using Functional Near-Infrared Spectroscopy [J ] . Front Hum Neurosci , 2020 ,( 14 ): 308 .
Saksida A , Ghiselli S , Bembich S , et al . Interdisciplinary Approaches to the Study of Listening Effort in Young Children with Cochlear Implants [J ] . Audiol Res , 2021 , 12 ( 1 ): 1 - 9 .
Chen Y , Luo Q , Liang M , et al . Children's Neural Sensitivity to Prosodic Features of Natural Speech and Its Significance to Speech Development in Cochlear Implanted Children [J ] . Front Neurosci , 2022 , 16 : 892894 .
Harrison SC , Lawrence R , Hoare DJ , et al . Use of Functional Near-Infrared Spectroscopy to Predict and Measure Cochlear Implant Outcomes: A Scoping Review [J ] . Brain Sci , 2021 , 11 ( 11 ): 1439 .
Fullerton AM , Vickers DA , Luke R , et al . Cross-modal functional connectivity supports speech understanding in cochlear implant users [J ] . Cereb Cortex , 2023 , 33 ( 7 ): 3350 - 3371 .
0
浏览量
17
下载量
0
CSCD
- 网络PDF下载
- WORD下载
- Meta-XML下载
- BibTeX下载
- Endnote下载
- RefMan 下载
- NoteExpress下载
- NoteFirst下载
关联资源
相关文章
相关作者
相关机构
- 技术支持由北京北大方正电子有限公司提供 京ICP备2023010756号-1
京公网安备11010502052338 - 本系统建议在Chrome、 IE9+ 以上版本浏览器阅读本站内容，360浏览器请切换至极速模式
- Cookies帮助我们提供服务并提供个性化体验。使用本网站，即表示您同意我们使用Cookies