耳鸣长期声治疗康复标志物探究

宫琴; 陈欢; 王慧敏; 李欣; 冀飞; 杨华; 伊海金

doi:10.3969/j.issn.1672-4933.2025.04.003

您当前的位置：

首页 >

文章列表页 >

耳鸣长期声治疗康复标志物探究

耳鸣研究 | 更新时间：2025-07-15

- 耳鸣长期声治疗康复标志物探究
- Study on Rehabilitation Biomarkers for Long-term Sound Therapy in Tinnitus
- 中国听力语言康复科学杂志 2025年23卷第4期页码：352-359
- 作者机构：
  
  1.清华大学生物医学工程学院北京 100084
  2.安徽工程大学电气工程学院安徽 241000
  3.北京清华长庚医院耳鼻咽喉头颈外科北京 102218
  4.解放军总医院第六医学中心耳鼻咽喉头颈外科医学部北京 100039
  5.北京协和医院北京 100730
- 作者简介：
  
  宫琴，博士副教授；研究方向：听觉系统的检测康复和认知工程 E-mail： gongqin@mail.tsinghua.edu.cn
- 基金信息：
  
  “十四·五”国家重点研发计划“诊疗装备与生物医用材料”耳鸣评估诊断治疗设备的研发及产业化(2023YFC2416200)
- DOI：10.3969/j.issn.1672-4933.2025.04.003
  中图分类号： R764.45
- 收稿日期：2025-03-21，
  
  纸质出版日期：2025-07-15
- 稿件说明：
移动端阅览
宫琴,陈欢,王慧敏等.耳鸣长期声治疗康复标志物探究[J].中国听力语言康复科学杂志,2025,23(04):352-359.

GONG Qin,CHEN Huan,WANG Hui-min,et al.Study on Rehabilitation Biomarkers for Long-term Sound Therapy in Tinnitus[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2025,23(04):352-359.
宫琴,陈欢,王慧敏等.耳鸣长期声治疗康复标志物探究[J].中国听力语言康复科学杂志,2025,23(04):352-359. DOI： 10.3969/j.issn.1672-4933.2025.04.003.

GONG Qin,CHEN Huan,WANG Hui-min,et al.Study on Rehabilitation Biomarkers for Long-term Sound Therapy in Tinnitus[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2025,23(04):352-359. DOI： 10.3969/j.issn.1672-4933.2025.04.003.

摘要

目的

探究个性化切迹掩蔽音乐疗法（tailor-made notched-masking music training，TNMMT）对主观性耳鸣长期治疗的有效性和客观定量的康复标志物，为客观定量评估耳鸣干预疗效提供科学依据。

方法

采用多中心研究的方法，涵盖多家医疗机构的主观性耳鸣患者。收集耳鸣患者第0、2、4、8周的行为学、主观量表和静息态脑电数据。

结果

主观性耳鸣患者经过8周TNMMT长期干预治疗后，耳鸣致残量表（tinnitus handicap inventory，THI）、耳鸣功能指数量表（tinnitus functional index，TFI）、视觉模拟量表（visual analogue scale，VAS）量表评分显著降低（

0.05）。耳鸣阈上响度显著降低（

0.05）。第2、4、8周静息态脑电功率谱数据与治疗前第0周相比，Delta波的功率谱密度呈现显著差异（

0.05）；此外，Theta波的功率谱在第0周与第2周、第0周与第8周也存在显著差异（

0.05）。按脑区进一步分析，受试者Delta波在额叶、左颞叶及顶叶区以及Theta波在左额叶、右颞叶和左中央区功率谱密度的变化显著（

0.05）。耳鸣量表与脑电功率谱的相关性分析结果显示，THI、TFI和VAS量表与Delta波的功率谱存在显著负相关。VAS_L评分与Delta波在右顶叶区呈现显著相关（

0.05），TFI与Delta波在左额叶区呈现显著相关（

0.05）。

结论

TNMMT在对主观性耳鸣长期干预治疗中有效，其干预过程中有神经可塑性现象的发生，Delta波功率谱密度与主观量表呈现相关性。

Abstract

Objective

To investigate the long-term efficacy of Tailor-made Notched-Masking Music Training (TNMMT) in treating subjective tinnitus and to identify objective quantitative biomarkers for rehabilitation

providing a scientific basis for objective evaluation of tinnitus and therapeutic outcomes.

Methods

A multicenter study involving subjective tinnitus patients was conducted. Behavioral data

subjective tinnitus scales

and resting-state electroencephalogram (EEG) data were collected at weeks 0

and 8 of TNMMT treatment.

Results

After 8 weeks of TNMMT intervention

subjective tinnitus patients showed significant reductions in Tinnitus Handicap Inventory (THI)

Tinnitus Functional Index (TFI)

and Visual Analogue Scale (VAS) scores (

0.05). Over-threshold loudness of tinnitus also decreased significantly (

0.05). Compared the baseline (week 0)

resting-state EEG po

wer spectra at weeks 2

and 8 revealed significant differences in Delta wave power spectral density (

0.05)

Additionally

Theta wave power spectra exhibited significant differences between week 0 and weeks 2/8 (

0.05). Regional analysis indicated significant changes in Delta wave power in the frontal

left temporal

and parietal lobes

as well as Theta wave power in the left frontal

right temporal

and left central regions. Correlation analysis demonstrated significant negative associations between THI

TFI

and VAS scores with Delta wave power. Specifically

VAS_L scores correlated significantly with Delta wave power in the right parietal lobe (

0.05)

and TFI scores correlated with Delta power in the left frontal lobe (

0.05).

Conclusion

The TNMMT demonstrates efficacy in long-term intervention for subjective tinnitus

with neuroplasticity phenomena observed during the treatment. Significant correlations were identified between delta band power spectral density and subjective rating scales.

关键词

Keywords

references

孔维佳 , 王洪田 , 余力生 , 等 . 耳鸣的诊断与治疗(一) [J ] . 临床耳鼻咽喉头颈外科杂志 , 2010 , 24 ( 1 ): 35 - 40 .

Biswas R. , Lugo A , Akeroyd MA , et al . Tinnitus prevalence in Europe: a multi-country cross-sectional population study [J ] . The Lancet Regional Health - Europe , 2022 , 12 : 100250 .

McCormack A , Edmondson-Jones M , Somerset S , et al . A systematic review of the reporting of tinnitus prevalence and severity [J ] . Hearing Research , 2016 , 337 ( 7 ): 70 - 79 .

卢兢哲 , 钟萍 , 郑芸 . 欧洲多学科耳鸣指南:诊断、评估和治疗 [J ] . 听力学及言语疾病杂志 , 2020 , 28 ( 1 ): 110 - 114 .

贺璐 , 王国鹏 , 彭哲 , 等 . 耳鸣临床应用指南 [J ] . 听力学及言语疾病杂志 , 2015 , 23 ( 2 ): 116 - 139 .

Maxwell SK , Robinson MJ , Hoffmann Ines , et al . Intratympanic Administration of OTO-313 Reduces Tinnitus in Patients With Moderate to Severe, Persistent Tinnitus: A Phase 1/2 Study [J ] . Otology & Neurotology , 2021 , 42 ( 10 ): e1625 - e1633 ..

Tunkel David E , Bauer Carol A , Sun Gordon H , et al . Clinical Practice Guideline: Tinnitus [J ] . Otolaryngology-Head and Neck Surgery , 2014 , 151 ( S2 ): S1 - S40 .

Barros Anna Carolina Marques Perrella de , Lopes Rhayane Vitória , Gil Daniela , et al . Auditory training for tinnitus treatment: a scoping review [J ] . Brazilian journal of otorhinolaryngology , 2023 , 90 ( 1 ): 101361 - 101361 .

Okamoto Hidehiko , Stracke Henning , Stoll Wolfgang , et al . Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity [J ] . Proceedings of the National Academy of Sciences of the United States of America , 2010 , 107 ( 3 ): 1207 - 1210 .

Stein Alwina , Wunderlich Robert , Lau Pia , et al . Clinical trial on tonal tinnitus with tailor-made notched music training [J ] . BMC neurology , 2016 , 16 ( 1 ): 38 .

Wunderlich Robert , Lau Pia , Stein Alwina , et al . Impact of Spectral Notch Width on Neurophysiological Plasticity and Clinical Effectiveness of the Tailor-Made Notched Music Training [J ] . PloS one , 2015 , 10 ( 9 ): e0138595 .

宫琴 , 王赫 , 马涛 , 等 . 一种耳鸣治疗声优化算法的研究 [J ] . 仪器仪表学报 , 2023 , 44 ( 3 ): 172 - 181 .

宫琴 , 王赫 , 朱敏 , 等 . 一种个性化耳鸣检测治疗仪的研发 [J ] . 清华大学学报(自然科学版) , 2023 , 63 ( 12 ): 2076 - 2084 .

焦粤农 , 于锋 , 钟胜长 , 等 . 中文译本耳鸣致残量表的临床应用研究 [J ] . 临床耳鼻咽喉头颈外科杂志 , 2016 , 30 ( 11 ): 907 - 910 .

Meikle MB , Henry JA , Griest SE , et al . The tinnitus functional index: development of a new clinical measure for chronic, intrusive tinnitus [J ] . Ear and hearing , 2012 , 33 ( 2 ): 153 - 176 .

Kathryn Fackrell , Deborah AH , Johanna GB , et al . Psychometric properties of the Tinnitus Functional Index (TFI): Assessment in a UK research volunteer population [J ] . Hearing Research , 2016 , 335 ( 5 ): 220 - 235 .

Weisz Nathan , Hartmann Thomas , Müller Nadia , et al . Alpha rhythms in audition: cognitive and clinical perspectives [J ] . Frontiers in psychology , 2011 , 2 ( 4 ): 73 - 88 .

涂艺 , 白忠 . 耳鸣的评估及治疗 [J ] . 世界最新医学信息文摘 , 2018 , 18 ( A4 ): 55 - 56,58 .

LI Gang , LI Ming , ZHANG Jianning . Mechanism and research progresses of personalized music in the treatment of tinnitus [J ] . Journal of Clinical Otorhinolaryngology Head and Neck Surgery , 2021 , 35 ( 1 ): 91 - 95 .

田如如 , 刁明芳 , 孙建军 . 主观性耳鸣的声治疗——机制与频率选择的演变 [J ] . 实用医学杂志 , 2016 , 32 ( 15 ): 2581 - 2583 .

Min Zhu , Qin Gong . Corrigendum: EEG spectral and microstate analysis originating residual inhibition of tinnitus induced by tailor-made notched music training [J ] . Frontiers in Neuroscience , 2024 , 17 : 1355150 - 1355150 .

Houdayer E , Teggi R , Velikova S , et al . Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study [J ] . Clinical Neurophysiology , 2015 , 126 ( 12 ): 2356 - 2365 .

Adjamian P , Sereda M , Zobay O , et al . Neuromagnetic indicators of tinnitus and tinnitus masking in patients with and without hearing loss [J ] . Journal of the Association for Research in Otolaryngology , 2012 , 13 : 715 - 731 .

Meyer M , Luethi MS , Neff P , et al . Disentangling Tinnitus Distress and Tinnitus Presence by Means of EEG Power Analysis [J ] . Neural Plasticity , 2014 , 2014 : 1 - 13 .

Yuan S , Zhou W , Wu Q , et al . Epileptic Seizure Detection with Log-Euclidean Gaussian Kernel-Based Sparse Representation [J ] . International Journal of Neural Systems , 2016 , 26 ( 3 ): 1650011 .

Wang Y , Qiu S , Ma X , et al . A prototype-based SPD matrix network for domain adaptation EEG emotion recognition [J ] . Pattern Recognition , 2021 , 110 : 107626 .

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

耳鸣评估检测方法：从临床实践到多模态整合

耳鸣量表的评估方法与临床应用

基于PERMA模式的积极心理干预对耳鸣患者的临床疗效

从认知角度看耳鸣与听配能的关系

人工耳蜗植入对成人语后聋患者耳鸣的影响