听觉重塑中时间因素对人工耳蜗植入后电诱发中潜伏期反应的影响分析

鲁兆毅; 潘滔; 王宇; 马芙蓉

doi:10.3969/j.issn.1672-4933.2024.04.005

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听觉重塑中时间因素对人工耳蜗植入后电诱发中潜伏期反应的影响分析

特殊病例的人工耳蜗植入 | 更新时间：2026-07-11

- 听觉重塑中时间因素对人工耳蜗植入后电诱发中潜伏期反应的影响分析
- Analysis of the Effects of Temporal Factors on Electrically Evoked Auditory Middle Latency Response after Cochlear Implantation in Auditory Remodeling
- 中国听力语言康复科学杂志 2024年22卷第4期页码：351-355
- 作者机构：
  
  北京大学第三医院北京 100191
- 作者简介：
  
  鲁兆毅博士副主任医师；研究方向：耳科学，人工耳蜗听觉电生理
  潘滔，E-mail：pantao6422@163.com
  马芙蓉，E-mail：furongma@126.com
- 基金信息：
  
  北京大学第三医院海淀创新转化专项(HDCXZHKC2022211)
- DOI：10.3969/j.issn.1672-4933.2024.04.005
  中图分类号： R764.43
- 收稿：2024-04-09，
  
  纸质出版：2024-07-15
- 稿件说明：
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鲁兆毅,潘滔,王宇等.听觉重塑中时间因素对人工耳蜗植入后电诱发中潜伏期反应的影响分析[J].中国听力语言康复科学杂志,2024,22(04):351-355.

LU Zhao-yi,PAN Tao,WANG Yu,et al.Analysis of the Effects of Temporal Factors on Electrically Evoked Auditory Middle Latency Response after Cochlear Implantation in Auditory Remodeling[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2024,22(04):351-355.
鲁兆毅,潘滔,王宇等.听觉重塑中时间因素对人工耳蜗植入后电诱发中潜伏期反应的影响分析[J].中国听力语言康复科学杂志,2024,22(04):351-355. DOI： 10.3969/j.issn.1672-4933.2024.04.005.

LU Zhao-yi,PAN Tao,WANG Yu,et al.Analysis of the Effects of Temporal Factors on Electrically Evoked Auditory Middle Latency Response after Cochlear Implantation in Auditory Remodeling[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation,2024,22(04):351-355. DOI： 10.3969/j.issn.1672-4933.2024.04.005.

摘要

目的

对影响人工耳蜗植入后电诱发中潜伏期反应（electrically evoked auditory middle latency response， EMLR）的时间因素，包括植入时年龄、植入后时间及现年龄等进行分析研究，探究听觉重塑过程中不同时间因素的影响。

方法

对46例2008年～2014年在北京大学第三医院耳鼻咽喉科进行人工耳蜗植入的患者在术后进行EMLR测试。比较语前聋儿童与语后聋成人EMLR的差异，以及语前聋儿童中现年龄、植入时年龄及植入后时间等因素对EMLR的影响。

结果

语前聋儿童EMLR各波潜伏期及波间潜伏期普遍较成人组长，各波间幅值普遍较成人组大，其中Po、Na、Pa、Nb及Pb波潜伏期，PoNa、NaPa及PaNb波间潜伏期，PoNa、NaPa、PaNb及NbPb波间幅值均存在统计学差异（

0.05）。语前聋儿童中，Pa、Nb波潜伏期及NaPa波间期与现年龄及植入后时间存在显著负相关、与植入时年龄存在显著正相关（

0.05）。

结论

EMLR在语前聋儿童与语后聋成人存在较显著差异，对于语前聋儿童，较大的年龄、较长的植入时间、较小的植入年龄对应更为成熟的EMLR波形，提示上述因素在听觉重塑过程中的重要性。

Abstract

Objective

To study the temporal factors affecting the electrically evoked auditory middle latency response (EMLR) after cochlear implantation

including age at implantation

post-implantation duration

and present age

in order to investigate the effects of different temporal factors in the process of auditory remodeling.

Methods

Forty-six patients who underwent cochlear implantation at the ENT Department

Peking University Third Hospital between 2008 and 2014 were tested for EMLR after surgery. Differences in EMLR between pre-lingual children and post-lingual adults were compared

as well as the effects of temporal factors such as present age

age at implantation

and post-implantation duration on EMLR in pre-lingual children.

Results

The latencies and intervals were generally longer and the inter-peak amplitudes were generally larger in the pre-lingual children than in the adults

with statistically significant differences (

0.05) in Po

and Pb latencies

PoNa

NaPa

and PaNb intervals

and PoNa

NaPa

PaNb

and NbPb inter-peak amplitudes on EMLR. In pre-lingual children

Pa and Nb latencies and NaPa intervals showed significant negative correlations with present age and post-implantation duration

and positive correlations with age at implantation (

0.05).

Conclusion

There were significant differences in EMLR between pre-lingual children and post-lingual adults. In pre-lingual children

older age

longer post-implantation duration

and younger age at implantation corresponded to more mature EMLR waveforms

suggesting the importance of the above factors in the process of auditory remodeling.

关键词

Keywords

references

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