中国听力语言康复科学杂志

2020, v.18;No.99(02) 111-116

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腺样体切除联合鼓膜置管术治疗儿童分泌性中耳炎有效性及安全性的meta分析
Efficacy and Safety of Adenoidectomy Combined with Tympanostomy in the Treatment of Children with Secretory Otitis Media: A Meta-Analysis

陈英;张海利;
CHEN Ying;ZHANG Hai-li;

摘要(Abstract):

目的运用meta分析法分析腺样体切除联合鼓膜置管术治疗儿童分泌性中耳炎的有效性及安全性。方法检索PubMed、EMBASE、MEDLINE、Cochrane、CBM、万方数据库,中国知网,维普信息资源系统,收集2019年9月~2000年1月已发表的相关文献,本研究的随机对照研究采用Cochrane-hand-book中提供的RiskofBiasTable标准对符合纳入标准的文献进行质量评价,使用ReviewManager(版本5.3)进行meta分析、异质性检验、并绘制森林图。结果共纳入11个随机对照研究,患者总数为1240例,meta分析结果显示:与单纯鼓膜置管术相比,联合腺样体切除可明显提高分泌性中耳炎的总有效率[RR=1.23,95%CI=(1.17,1.29),Z=7.97,P<0.05];并且减少治愈后的复发率[RR=4.67,95%CI=(2.69,8.12),Z=5.46,P<0.05];降低不良反应的发生率[RR=3.54,95%CI=(2.38,5.27),Z=6.24,P<0.05]。结论腺样体切除联合鼓膜置管术治疗分泌性中耳炎可提高有效率,减少治愈后的复发率,降低不良反应的发生率,为临床医生及患者提供诊疗依据。
Objective To analyze the efficacy and safety of adenoidectomy combined with tympanostomy in the treatment of secretory otitis media in children. Methods Electronic retrieval PubMed, EMBASE, MEDLINE and the Cochrane, CBM, WAN FANG DATA, CNKI and VIP information resources system collected published literature about adenoidectomy combined study of surgery in the treatment of secretory otitis media between September 2019 to January 2000, The Cochrane-hand-book provided in the Risk of Bias, Table standard to meet eligibility criteria of the quality of literature evaluation,Review Manager(version 5.3) was used for meta-analysis, heterogeneity test, and forest mapping. Results 11 randomized controlled studies were included, with a total of 1,240 patients. Meta-analysis results showed that combined adenoidectomy significantly improved the overall effective rate of secretory otitis media compared with tympanostomy alone [RR=1.23,95%CI=(1.17,1.29), Z=7.97, P<0.05].The recurrence rate after treatment was reduced [RR=4.67, 95%CI =(2.69,8.12), Z=5.46, P<0.05].The incidence of adverse reactions was reduced [RR=3.54, 95%CI=(2.38,5.27), Z=6.24, P<0.05].Conclusion Adenoidectomy combined with tympanotympanum catheterization in the treatment of secretory otitis media can improve the effective rate, reduce the recurrence rate after treatment, reduce the incidence of adverse reactions, and provide the diagnosis and treatment basis for clinicians and patients.

关键词(KeyWords): 分泌性中耳炎;腺样体切除;鼓膜置管术;疗效;meta分析
Secretory otitis media;Adenoidectomy;Tympanoplasty;Efficacy;Meta-analysis

Abstract:

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作者(Author): 陈英;张海利;
CHEN Ying;ZHANG Hai-li;

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